SPORE IN BREAST CANCER

约翰·霍普金斯医学机构的乳腺癌卓越研究专业项目（SPORE）汇集了一个高度互动的、多学科的乳腺癌转化研究项目。SPORE包括四个研究项目和七个综合项目，涵盖风险评估、诊断、分期、治疗和预防等领域。项目1：发展分子标记来定义乳腺癌的进展和分类。项目1A，乳腺癌分子标记（Saraswati Sukumar博士），项目1B，乳腺癌分子表型（Edward Gabrielson医学博士）。2A项目，乳腺癌分子检测（James Herman医学博士）。项目3，乳腺癌治疗和预防分子策略的发展。3A项目，新型多胺类似物治疗乳腺癌（Robert Casero博士）；项目3B，使用去甲基化和组蛋白去乙酰化药物治疗乳腺癌（Nancy Davidson药物治疗乳腺癌）（Nancy Davidson， M.D.）；3C项目，疫苗：乳腺癌预防的新范例（Elizabeth Jaffee，医学博士）。项目4 4A，乳腺癌进展的分子流行病学（Kathy Helzlsour M.D， MHC）。这七个研究项目由三个核心支持：核心1，管理和通信（Nancy Davidson， M.D.）。核心2，人类标本资源和数据库（马克谢尔曼医学博士）促进对转化性乳腺癌研究感兴趣的个人的职业发展。

This proposal for a Specialized Program of Research Excellence (SPORE) in Breast Cancer at The Johns Hopkins Medical Institutions brings together a highly interactive, multi-disciplinary program of translational research in breast cancer. The SPORE includes four research programs with seven integrated projects spanning the fields of risk assessment, diagnosis, staging, treatment, and prevention. Program 1, Development of molecular markers to define breast cancer progression and classification. Project 1A, Molecular markers for breast cancer (Saraswati Sukumar Ph.D.), Project 1B, Molecular phenotypes of breast cancer (Edward Gabrielson M.D.). Program 2 Project 2A, Molecular detection of breast cancer (James Herman M.D.). Program 3, Development of molecular strategies for breast cancer therapy and prevention. Project 3A, Novel polyamine analogs for breast cancer treatment (Robert Casero Ph.D.); Project 3B, Use of demethylating and histone deacetylating agents to treat breast cancer (Nancy Davidson agents to treat breast cancer (Nancy Davidson, M.D.); Project 3C, Vaccines: A new paradigm for breast cancer prevention (Elizabeth Jaffee, M.D.). Program 4 Project 4A, Molecular epidemiology of progression to breast cancer (Kathy Helzlsour M.D., MHC). These seven research projects are supported by three cores: Core 1, Administration and communications (Nancy Davidson, M.D.). Core 2, Human specimen resource and database (Mark Sherman M.D.) To facilitate career development of individuals with an interest in translational breast cancer research.