Very High Energy Electron (VHEE) Radiotherapy: Image Guidance and Dose Delivery

甚高能电子 (VHEE) 放射治疗：图像引导和剂量输送

• 批准号: 2320648
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2320648
• 关键词: Very; Energy; Electron; VHEE; Radiotherapy

Radiotherapy depends on accurate delivery of a certain amount of dose (enough to kill the tumour) to the right place. For this purpose modern radiotherapy equipment has extensive QA and is combined with advanced image guidance capabilities.VHEE (Very High Energy Electron) radiotherapy (in the energy range of ~70 to 250 MeV) is currently under development and promises rapid delivery of dose by means of electromagnetically steered e-beams. Because of the high energy, the delivery is range-insensitive and hence it is generally applicable even in inhomogeneous parts of the body. It also has the potential to be significantly cheaper than radiotherapy equipment in use at present.Furthermore VHEE has the potential for extremely rapid and large dose delivery to cancerous tissue. It is also able to take advantage of recent in vivo "FLASH" studies -in which a high dose is delivered to tissue extremely rapidly -allowing complete eradication tumours while promising reduction in the occurrence and severity of early and late complications affecting normal tissue. This studentship entails exploring the feasibility of integrating VHEE therapy with absolute dose measurement, and image guidance. The advantage of rapid dose delivery (within seconds), makes dose measurement more complicated, and also image guidance, because localisation of the tumour has to be performed in a similar timeframe.In a future practical application of VHEE radiotherapy, both issues must be addressed. In this project we will study:1 Effect of patient motion on image guidance followed by flash delivery. This is relevant for VHEE as well as protons.2 Relate treatment time to accuracy requirements.3 Explore in-vivo dosimetry based on flat panel imagers.As the project progresses we anticipate a close collaboration with clinicians and clinical scientists developing. This project has the potential to develop a new paradigm in radiotherapy: entailing rapid delivery of very high doses to patients via high energy electron beams. There is a focus in this project on image guidance and dose delivery -two essential elements that have been lacking from current studies but are integral to the practicality of VHEE facility. The collaboration with experts in this field from the Christie NHS Trust is important to this project Simulation of dose delivery with GEANT4 and experiments at the Christie NHS Trust, and CERN are important to the success of this research.

放射治疗依赖于将一定量的剂量（足以杀死肿瘤）准确地输送到正确的位置。VHEE（甚高能电子）放射治疗（能量范围为~70至250 MeV）目前正在开发中，并有望通过电磁操纵电子束快速输送剂量。由于高能量，输送对范围不敏感，因此即使在身体的不均匀部位也通常适用。它也有可能比目前使用的放射治疗设备便宜得多。此外，VHEE有可能极快速和大剂量输送到癌组织。它还能够利用最近的体内“FLASH”研究-其中高剂量非常迅速地递送到组织-允许完全根除肿瘤，同时有望减少影响正常组织的早期和晚期并发症的发生率和严重程度。这个学生需要探索将VHEE治疗与绝对剂量测量和图像引导相结合的可行性。快速剂量输送（几秒钟内）的优点使得剂量测量更加复杂，而且图像引导也更加复杂，因为肿瘤的定位必须在类似的时间范围内进行。在VHEE放射治疗的未来实际应用中，这两个问题都必须得到解决。在这个项目中，我们将研究：1患者运动对图像引导的影响，然后进行闪光传输。这与VHEE以及质子相关。2将治疗时间与精度要求联系起来。3探索基于平板成像仪的体内剂量测定。随着项目的进展，我们预计将与临床医生和临床科学家密切合作，开发出更好的剂量测定方法。该项目有可能开发一种新的放射治疗模式：通过高能电子束向患者快速提供非常高的剂量。本项目的重点是图像引导和剂量输送-这两个基本要素在当前研究中一直缺乏，但对VHEE设施的实用性不可或缺。与科视Christie NHS Trust在该领域的专家合作对该项目非常重要，GEANT 4剂量输送模拟和科视Christie NHS Trust和CERN的实验对该研究的成功非常重要。