Very High Energy Electron (VHEE) Radiotherapy (RT): A potential New Paradigm in Cancer Treatment

甚高能电子 (VHEE) 放射治疗 (RT)：癌症治疗的潜在新范式

• 批准号: 2326574
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2326574
• 关键词: Very; Energy; Electron; VHEE; Radiotherapy

VHEE radiotherapy (in the energy range of ~100 to 250 MeV) could offer benefits in radiotherapy treatments due to more favourable dose distributions in comparison to current photon and electron therapy and insensitivity to tissue inhomogeneities (apparent e.g. in the lung and bowel treatments). It also has the potential to be significantly cheaper than extant radiotherapies in use, such as proton radiotherapy, and could allow rapid delivery of dose - as limited mechanical motion is envisaged in a system consisting of electromagnetically steered e-beams. VHEE RT could offer extremely rapid and large dose delivery to cancerous tissue, therefore taking advantage of recently reported FLASH effect, which exhibits as increase differential response between normal and tumorous tissue. This could offer significant benefits in future radiotherapy, however lack of accurate and traceable dosimetry is hampering the rapid progress in this area. The PhD student will focus on dosimetry of VHEE beams performing measurements at Cockcroft Institute's CLARA facility and CLEAR facility at CERN using absolute, secondary standard and relative dosimetry methods. This work will be complemented by comprehensive Monte Carlo modelling required to plan experiments, calculate required correction and conversion factors and understand physical processes involved in generation of the beam, transport and dose deposition in the phantoms and patients. Preliminary radiobiological studies are also envisaged to assess the efficacy of VHEE beam

VHEE放射治疗(能量范围为~100至250 MeV)可在放射治疗中带来好处，因为与当前的光子和电子治疗相比，VHEE放射治疗的剂量分布更有利，并且对组织不均匀(例如，在肺和肠道治疗中明显)不敏感。它还有可能比现有的放射治疗方法(如质子放射治疗)便宜得多，并可以快速输送剂量--因为在由电磁控制的电子束组成的系统中，设想了有限的机械运动。VHEE RT可以提供极快和大剂量的肿瘤组织递送，因此利用了最近报道的闪光效应，表现为增加正常组织和肿瘤组织之间的差异反应。这可能在未来的放射治疗中提供显著的好处，但缺乏准确和可追踪的剂量测量正在阻碍这一领域的快速进展。这位博士生将专注于在Cockcroft Institute的Clara设施和CERN的Clear设施使用绝对、二级标准和相对剂量测定方法进行测量的VHEE束流的剂量测定。这项工作将得到全面的蒙特卡罗模型的补充，该模型需要规划实验，计算所需的校正和转换因子，并了解在模体和患者中产生束流、传输和剂量沉积所涉及的物理过程。初步的放射生物学研究也被设想用来评估VHEE射束的疗效。