SynBio Routes to Next Generation Green Bio-Surfactants from Sustainable Feedstocks (summary to follow)

SynBio 从可持续原料生产下一代绿色生物表面活性剂的路线（摘要如下）

• 批准号: 2327018
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2327018
• 关键词: SynBio; Routes; Next; Generation; Green

In light of major concerns over climate change and oil use, there is a strong drive for industry to reduce its overall environmental footprint through the development of green and sustainable manufacturing practices. In this project, we aim to develop sustainable biosynthetic routes and engineered cell factories for the conversion of unsaturated fatty acid feedstocks to furan-containing fatty acids, an important class of natural products that have great potential to serve as next generation bio-derived surfactants with interesting functional properties.The project is firmly embedded at the interface of chemistry and biology, a key driver for the BBSRC in the 'Exploiting new ways of working' agenda. It draws on key bioscience skills, including protein engineering, directed evolution and enzyme characterization, and specifically exploits a multi-disciplinary approach to the sustainable production of high-value molecules, which is a major objective in the industrial biotechnology sector.

鉴于对气候变化和石油使用的重大关切，工业界有强烈的动力通过发展绿色和可持续的制造做法来减少其总体环境足迹。在这个项目中，我们的目标是开发可持续的生物合成路线和工程细胞工厂，将不饱和脂肪酸原料转化为含呋喃脂肪酸，这是一类重要的天然产品，具有巨大的潜力作为下一代生物衍生表面活性剂，具有有趣的功能特性。该项目牢牢植根于化学和生物学的接口，这是BBSRC‘开发新的工作方式’议程中的关键驱动力。它利用关键的生物科学技能，包括蛋白质工程、定向进化和酶特性，并具体利用多学科方法可持续地生产高价值分子，这是工业生物技术部门的一个主要目标。