Inova 500 MHz Nuclear Magnetic Resonance System

Inova 500 MHz 核磁共振系统

• 批准号: 6732500
• 负责人: David W MacMillan
• 金额: $ 49.68万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6732500
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; nuclear magnetic resonance spectroscopy; structural biology

DESCRIPTION: (provided by applicant) This proposal outlines a detailed plan to integrate a new 500 MHZ Inova NMR Spectrometer into the Instrumentation Facilities in the Division of Chemistry and Chemical Engineering at Caltech. The major application of this high field NMR instrument will be for the purpose of structure determination of complex organic and inorganic molecular architectures arising from synthetic, semisynthetic, and biosynthetic sequences and protocols. The research activities of seven major user groups, as well as many minor user groups (not listed) in the Division will greatly benefit from this new spectrometer and in many cases new research directions within existing programs will be enabled by the presence of such critical instrumentation. Over the last 30 years, high field NMR spectrometers have come to represent a fundamental research tool among major university chemistry departments. NMR is a non-destructive characterization method that provides unique, detailed information about the geometry and constitution of inorganic and organic structure in a routine, high-throughput fashion. As a consequence, these instruments have become the analytical workhorse for chemical researchers across a broad variety of fields that rely upon the synthesis of small and large molecular architecture. More specifically, thousands of NMR spectroscopy characterization experiments are performed on a weekly basis within most traditional chemistry departments in academia and industry. In this context, the current instrumentation infrastructure for 500 MHz NMR analysis in the Division of Chemistry and Chemical Engineering at Caltech is severly limited. At the present time, the department has one Bruker AMX 500 MHz spectrometer that was purchased in 1986. This spectrometer has exceeded its expected lifetime for usage. Limitations arising from poor sensitivity, poor resolution and outdated software has rendered this instruement effectively obsolete and we plan to remove this instrument from our facility in the near future. In addition, to the existing departmental instrumentation, we currently have a 600 MHz Varian Unity Plus instrument; that is used almost exclusively for structural determination associated with complex biological molecules. The requirements of high sensitivity that are required for this system effectively preclude its use as a routine or high throughput departmental instrument. The Institute has made a major committment to oversee the maintenance and implementation of technical expertise to operate this instrument over an extended time frame. The Institute and the Division will provide the necessary funds towards the salary of the NMR facility manager and resources to provide the necessary infrastructure to house this instrument. The new 500 MHz instrument will be housed in contiguous space with the current Division NMR instruments.

描述：（由申请人提供）该提案概述了将新型 500 MHZ Inova NMR 波谱仪集成到加州理工学院化学与化学工程系仪器设施中的详细计划。这种高场核磁共振仪的主要应用是确定由合成、半合成和生物合成序列和方案产生的复杂有机和无机分子结构的结构。该部门的七个主要用户组以及许多次要用户组（未列出）的研究活动将极大地受益于这种新的光谱仪，并且在许多情况下，现有计划中的新研究方向将因这种关键仪器的存在而得以实现。在过去的 30 年里，高场核磁共振波谱仪已成为主要大学化学系的基础研究工具。 NMR 是一种非破坏性表征方法，能够以常规、高通量的方式提供有关无机和有机结构的几何形状和构成的独特、详细的信息。因此，这些仪器已成为依赖小分子结构和大分子结构合成的各个领域的化学研究人员的分析主力。更具体地说，数千个 NMR 波谱表征 学术界和工业界的大多数传统化学部门每周都会进行实验。在这种情况下，加州理工学院化学与化学工程系当前用于 500 MHz NMR 分析的仪器基础设施受到严重限制。目前，该部门拥有一台 1986 年购买的 Bruker AMX 500 MHz 光谱仪。该光谱仪已超过其预期使用寿命。由于灵敏度差、分辨率差和软件过时而产生的限制已经使该仪器实际上已经过时，我们计划在不久的将来从我们的设施中删除该仪器。此外，除了现有的部门仪器外，我们目前还有一台 600 MHz Varian Unity Plus 仪器；它几乎专门用于与复杂生物分子相关的结构测定。该系统所需的高灵敏度要求有效地排除了其作为常规或高通量部门的使用 乐器。该研究所做出了重大承诺，负责监督技术专业知识的维护和实施，以便在较长的时间内操作该仪器。这 研究所和该部门将为 NMR 设施经理的工资提供必要的资金，并提供安装该仪器所需的基础设施的资源。新的 500 MHz 仪器将与当前的 Division NMR 仪器安装在相邻的空间内。

项目成果

Electrochemical Preparation of Sm(II) Reagent Facilitated by Weakly Coordinating Anions

弱配位阴离子促进Sm(II)试剂的电化学制备

• DOI: 10.1002/chem.202301045
• 发表时间: 2023
• 期刊: Chemistry – A European Journal
• 作者: Ware, Skyler D.;Zhang, Wendy;Charboneau, David J.;Klein, Channing K.;Reisman, Sarah E.;See, Kimberly A.
• 通讯作者: See, Kimberly A.