Digitized Transmission Electron Microscope

数字化透射电子显微镜

• 批准号: 6733811
• 负责人: PAUL Nathan MCMILLAN
• 金额: $ 23.15万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-15 至 2005-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6733811
• 关键词: bioimaging /biomedical imaging; biomedical device power system; biomedical equipment purchase; digital imaging; transmission electron microscopy

DESCRIPTION (provided by applicant): Funds are requested for the acquisition of a modern, digital, transmission electron microscope to be installed within the Division of Core Research Laboratories at Rhode Island Hospital (the state's largest Brown University-affiliated teaching hospital and trauma center). The Morgani Model Transmission Electron Microscope will significantly benefit the research and teaching endeavors of the twelve NIH-Funded investigators whose projects are detailed in this submission and that of Brown University campus-based investigators, as well the work of hospital-based faculty that are based at the five other Brown-affiliated hospitals which collectively comprise the Brown University School Of Medicine. We currently have a decrepit 32 year old Philips 300 transmission electron microscope. Several Major components (e.g., the high voltage supply, the mercury diffusion vacuum pump, the camera transport mechanism, and at least two lens supply modules {aka K units}) are functionally unreliable and frank failure of these and/or other elements appears imminent. We have carefully considered the technical capabilities and costs of current transmission electron microscopes. Instruments at the "low" end of their price ranges are adequate for our uses, give excellent resolution (equal to or very near high-end models) and considerable flexibility, and are well suited to the research projects in this proposal, as well as likely future projects. The Philips (FEI) model Morgani 268 is a 100 kV microscope with a conventional motorized stage with a 6 degree tilt & high-resolution digital camera system. The microscope is fully digitized, controlled by an upgradable PC that is also used for digital image capture. This is a recently introduced model in the Philips line, and is the most modern of those considered. It offers exceptional value; is designed for the "cell biology, pathology, ultrastructural molecular biology" category of users; and is well suited to our needs. Unlike models that are in the middle or near the end of their product runs, this unit is at the beginning of its production period. Consequently, the microscope will be supported by the manufacturer with service and parts further into the future than the others, giving it a longer useful life span. Therefore, due to capability, versatility, needs appropriateness, upgradability, and overall value, we have specified the Philips Morgani 268 in this funding request.

描述（由申请人提供）：资金要求购买一个现代化的，数字化的，透射电子显微镜将安装在核心研究实验室在罗得岛医院（该州最大的布朗大学附属教学医院和创伤中心）的部门。Morgani模型透射电子显微镜将大大有利于12个NIH资助的研究人员的研究和教学工作，他们的项目在本申请中详细介绍，布朗大学校园为基础的研究人员，以及医院为基础的教师的工作，这些教师位于布朗大学医学院的其他五家附属医院。我们目前有一个破旧的32岁飞利浦300透射电子显微镜。几个主要组成部分（例如，高压电源、汞扩散真空泵、照相机传送机构和至少两个透镜供应模块（也称为K单元）在功能上是不可靠的，并且这些和/或其它元件的明显故障似乎即将发生。我们仔细考虑了当前透射电子显微镜的技术能力和成本。在其价格范围的“低”端的仪器足以满足我们的使用，提供出色的分辨率（等于或非常接近高端型号）和相当大的灵活性，非常适合本提案中的研究项目，以及可能的未来项目。飞利浦（FEI）型号Morgani 268是一种100 kV显微镜，具有传统的电动载物台，具有6度倾斜和高分辨率数码相机系统。显微镜是完全数字化的，由一台可拆卸的PC控制，也用于数字图像采集。这是飞利浦系列中最近推出的一款，是所考虑的最现代的型号。它提供了特殊的价值;是专为“细胞生物学、病理学、超微结构分子生物学”类别的用户设计的，非常适合我们的需要。与处于产品运行中期或接近尾声的型号不同，该单元处于生产期的开始阶段。因此，显微镜将由制造商提供服务和部件，使其比其他显微镜更长的使用寿命。因此，由于能力、多功能性、需求适当性、可重复性和整体价值，我们在本资金申请中指定了Philips Morgani 268。