Acquisition of a 500 MHz NMR Spectrometer

描述：(由申请人提供)：购买一台新的核磁共振光谱仪是为了给加州大学欧文分校化学系的核磁共振设施带来新的能力。该设施支持一群非常活跃的有机和生物有机组织的研究计划，其中许多人在健康相关研究方面得到了美国国立卫生研究院的广泛支持。目前的设施中有三台老旧的、经常使用的核磁共振光谱仪。该设施最大的需求是需要更高的灵敏度来分析小样本，以及需要更多的仪器时间来处理设施的沉重负担。通过这项提案的支持，将购买一台配备13C/1H低温探头的新的500 MHz核磁共振光谱仪。低温探测器系统比普通探测器敏感得多，普通探测器本身也比我们老化的探测器更敏感。我们预计新仪器的灵敏度将提高四倍以上，增加的灵敏度将使我们能够在小得多的样品上收集核磁共振数据，并在比目前有限数量的材料上更短的时间内收集核磁共振数据。该仪器还将减轻现有机器的一些负担，并提供更多的仪器时间。这一新仪器将为核磁共振设施带来亟需的新能力，并将极大地促进本提案的PI和CO-PI的研究计划。

DESCRIPTION: (provided by applicant): The purchase of a new NMR spectrometer is proposed to bring new capabilities to the NMR facility in the Chemistry Department at the University of California, Irvine. The facility supports the research programs of a very active group of organic and bioorganic, many of whom have extensive support from the NIH for their health-related research. The current facility houses three old and heavily used NMR spectrometers. The greatest needs in the facility are for greater sensitivity to analyze small samples and for more instrument time to handle the heavy burden on the facility. A new 500MHz NMR spectrometer equipped with a 13 C/1H cryoprobe will be purchased through support from this proposal. The cryoprobe system is much more sensitive than a normal probe, which is itself more sensitive than our aging probes. We expect a better than four-fold improvement in sensitivity from the new instrument, and that added sensitivity will allow us to collect NMR data on much smaller samples, and to collect NMR data in much less time than is currently possible on limited quantities of material. The instrument will also take some of the burden off the existing machines and provide more instrument time. This new instrument will bring much needed new capabilities to the NMR facility and will greatly facilitate the research programs of the PI and co-PIs of this proposal.