Acquisition of a 500 MHz NMR Spectrometer

产品说明：（申请人提供）：购买一台新的核磁共振光谱仪是为了给欧文市加州大学化学系的核磁共振设施带来新的能力。该设施支持一个非常活跃的有机和生物有机团体的研究计划，其中许多人都得到了NIH对其健康相关研究的广泛支持。目前的设施有三台旧的和大量使用的核磁共振光谱仪。该设施的最大需求是更高的灵敏度，以分析小样本，并为更多的仪器时间来处理设施的沉重负担。通过本提案的支持，将购买一台配备13 C/1H冷冻探针的新500 MHz NMR光谱仪。冷冻探针系统比普通探针灵敏得多，普通探针本身比我们的老化探针灵敏。我们预计新仪器的灵敏度将提高四倍以上，增加的灵敏度将使我们能够收集更小样品的NMR数据，并在比目前有限数量材料更短的时间内收集NMR数据。该仪器还将减轻现有机器的一些负担，并提供更多的仪器时间。这种新仪器将为NMR设备带来急需的新功能，并将大大促进本提案的PI和co-PI的研究计划。

DESCRIPTION: (provided by applicant): The purchase of a new NMR spectrometer is proposed to bring new capabilities to the NMR facility in the Chemistry Department at the University of California, Irvine. The facility supports the research programs of a very active group of organic and bioorganic, many of whom have extensive support from the NIH for their health-related research. The current facility houses three old and heavily used NMR spectrometers. The greatest needs in the facility are for greater sensitivity to analyze small samples and for more instrument time to handle the heavy burden on the facility. A new 500MHz NMR spectrometer equipped with a 13 C/1H cryoprobe will be purchased through support from this proposal. The cryoprobe system is much more sensitive than a normal probe, which is itself more sensitive than our aging probes. We expect a better than four-fold improvement in sensitivity from the new instrument, and that added sensitivity will allow us to collect NMR data on much smaller samples, and to collect NMR data in much less time than is currently possible on limited quantities of material. The instrument will also take some of the burden off the existing machines and provide more instrument time. This new instrument will bring much needed new capabilities to the NMR facility and will greatly facilitate the research programs of the PI and co-PIs of this proposal.