Acquisition of a 500 MHz NMR Spectrometer

描述：（由申请人提供）：购买一台新的核磁共振光谱仪是为了给加州大学尔湾分校化学系的核磁共振设备带来新的能力。该机构支持一个非常活跃的有机和生物有机群体的研究项目，其中许多人在健康相关的研究方面得到了美国国立卫生研究院的广泛支持。目前的设施有三个旧的和大量使用的核磁共振光谱仪。该设施最大的需求是对分析小样本的更高灵敏度和更多的仪器时间来处理设施的沉重负担。通过该提案的支持，将购买一台配备13 C/1H冷冻探针的新500MHz核磁共振光谱仪。冷冻探头系统比普通探头灵敏得多，而普通探头本身又比老化探头灵敏得多。我们预计新仪器的灵敏度将提高四倍以上，并且增加的灵敏度将使我们能够在更小的样品上收集NMR数据，并且在更短的时间内收集NMR数据，而目前在有限数量的材料上是可能的。该仪器还将减轻现有机器的一些负担，并提供更多的仪器时间。这台新仪器将为核磁共振设施带来急需的新功能，并将极大地促进本提案的PI和co-PI的研究计划。

DESCRIPTION: (provided by applicant): The purchase of a new NMR spectrometer is proposed to bring new capabilities to the NMR facility in the Chemistry Department at the University of California, Irvine. The facility supports the research programs of a very active group of organic and bioorganic, many of whom have extensive support from the NIH for their health-related research. The current facility houses three old and heavily used NMR spectrometers. The greatest needs in the facility are for greater sensitivity to analyze small samples and for more instrument time to handle the heavy burden on the facility. A new 500MHz NMR spectrometer equipped with a 13 C/1H cryoprobe will be purchased through support from this proposal. The cryoprobe system is much more sensitive than a normal probe, which is itself more sensitive than our aging probes. We expect a better than four-fold improvement in sensitivity from the new instrument, and that added sensitivity will allow us to collect NMR data on much smaller samples, and to collect NMR data in much less time than is currently possible on limited quantities of material. The instrument will also take some of the burden off the existing machines and provide more instrument time. This new instrument will bring much needed new capabilities to the NMR facility and will greatly facilitate the research programs of the PI and co-PIs of this proposal.