INIA: Consortium-Bioanalytical Core

INIA：生物分析核心联盟

• 批准号: 6694112
• 负责人: THOMAS R SUTTER
• 金额: $ 47.76万
• 依托单位: UNIVERSITY OF MEMPHIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6694112
• 关键词: Internet; alcoholism /alcohol abuse; biomedical facility; cooperative study; experimental designs; gene expression; high throughput technology; information dissemination; microarray technology; neurology; polymerase chain reaction; radioimmunoassay; statistics /biometry; steroids; western blottings

DESCRIPTION (provided by applicant): This application describes the Bioanalytical Core (C#4), one of five distributed core facilities of the Integrative Neuroscience Initiative on Alcoholism (INIA) Consortium, led by Dr. David Lovinger, Consortium Coordinator, Vanderbilt University Medical Center (VUMC), Nashville, TN. Dr. Thomas R. Sutter, is the PI of the Bioanalytical Core (C#4), Feinstone Center for Genomic Research, University of Memphis, Memphis, TN, with subcontracts to Dr. Leslie Morrow, University of North Carolina, Chapel Hill, NC, and Dr. William Taylor, University of Tennessee Health Science Center, Memphis, TN. The Bioanalytical Core fulfills several of the goals identified in the INIA RFA: RFA-AA-01-002 of the National Institute of Alcohol Abuse and Alcoholism: 1) It established a distributed core resource drawing on expertise from multiple research sites to provide both well established methods and to create a new resource within the alcohol research community, 2) this core brings established researchers from other areas to the alcohol field and 3) in addition to providing services, the Bioanalytical Core acts as a collaborative research partner of the Research and Pilot Project Components in which it participates; assisting in experimental design, data collection and analysis, interpretation, and information dissemination through the Bioinformatics Core (C#3) and ultimately, through peer-reviewed publication. Through the research interactions between the scientists in the alcohol field and investigators from other fields, this core should bring new approaches and perspectives to the proposed studies on the neurobiological mechanisms underlying aspects of neuroadaptation to alcohol. The Bioanalytical Core (C#4) serves and collaborates with six Research Components, RC1 (Cellular Mechanisms in Stress-Alcohol Interactions), RC2 (Systemic/Behavioral Mechanisms), RC3 (ENU Mutagenesis), RC4 (QTL Analysis), RC5 (Primate Model), RC6 (Schedule-induced Polydypsia and Excessive Alcohol Drinking in Mice), and one Pilot Project, P4 (Massively Parallel QTL Mapping using Microarray).

描述（由申请人提供）： 本申请描述了生物分析核心（C#4）， 综合神经科学倡议的分布式核心设施， 酒精中毒（INIA）联盟，由大卫Lovinger博士领导，联盟 协调员，范德比尔特大学医学中心（VUMC），纳什维尔，田纳西州。博士 托马斯河Sutter是Feinstone中心生物分析核心（C#4）的PI 基因组研究，孟菲斯大学，孟菲斯，田纳西州，与分包合同， 博士莱斯利莫罗，北卡罗来纳州，查佩尔山，北卡罗来纳大学和博士。 William Taylor，田纳西大学健康科学中心，田纳西州孟菲斯。 生物分析核心实现了INIA中确定的几个目标 RFA：国家酒精滥用和酒精中毒研究所的RFA-AA-01-002： 1)它建立了一个分散的核心资源， 多个研究站点，以提供完善的方法，并创建 酒精研究界的一个新资源，2）这个核心带来了 从其他领域到酒精领域的研究人员; 3） 除了提供服务外，生物分析核心还作为一个合作伙伴， 研究和试点项目组成部分的研究伙伴，其中， 参与;协助实验设计，数据收集和分析， 通过生物信息学核心进行解释和信息传播 （C#3）并最终通过同行评审的出版物。通过研究 酒精领域的科学家和研究人员之间的互动 从其他领域，这个核心应该带来新的方法和观点， 建议的关于神经生物学机制的研究， 酒精的神经适应生物分析核心（C#4）用于 与六个研究部门合作，RC 1（应激-酒精的细胞机制） 相互作用）、RC 2（系统/行为机制）、RC 3（ENU 突变）、RC 4（QTL分析）、RC 5（灵长类动物模型）、RC 6（计划诱导 小鼠多饮症和过量饮酒），以及一个试点项目，P4 （使用微阵列进行大规模并行QTL定位）。