INIA: Consortium-Bioanalytical Core

INIA：生物分析核心联盟

• 批准号: 6694112
• 负责人: THOMAS R SUTTER
• 金额: $ 47.76万
• 依托单位: UNIVERSITY OF MEMPHIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6694112
• 关键词: Internet; alcoholism /alcohol abuse; biomedical facility; cooperative study; experimental designs; gene expression; high throughput technology; information dissemination; microarray technology; neurology; polymerase chain reaction; radioimmunoassay; statistics /biometry; steroids; western blottings

DESCRIPTION (provided by applicant): This application describes the Bioanalytical Core (C#4), one of five distributed core facilities of the Integrative Neuroscience Initiative on Alcoholism (INIA) Consortium, led by Dr. David Lovinger, Consortium Coordinator, Vanderbilt University Medical Center (VUMC), Nashville, TN. Dr. Thomas R. Sutter, is the PI of the Bioanalytical Core (C#4), Feinstone Center for Genomic Research, University of Memphis, Memphis, TN, with subcontracts to Dr. Leslie Morrow, University of North Carolina, Chapel Hill, NC, and Dr. William Taylor, University of Tennessee Health Science Center, Memphis, TN. The Bioanalytical Core fulfills several of the goals identified in the INIA RFA: RFA-AA-01-002 of the National Institute of Alcohol Abuse and Alcoholism: 1) It established a distributed core resource drawing on expertise from multiple research sites to provide both well established methods and to create a new resource within the alcohol research community, 2) this core brings established researchers from other areas to the alcohol field and 3) in addition to providing services, the Bioanalytical Core acts as a collaborative research partner of the Research and Pilot Project Components in which it participates; assisting in experimental design, data collection and analysis, interpretation, and information dissemination through the Bioinformatics Core (C#3) and ultimately, through peer-reviewed publication. Through the research interactions between the scientists in the alcohol field and investigators from other fields, this core should bring new approaches and perspectives to the proposed studies on the neurobiological mechanisms underlying aspects of neuroadaptation to alcohol. The Bioanalytical Core (C#4) serves and collaborates with six Research Components, RC1 (Cellular Mechanisms in Stress-Alcohol Interactions), RC2 (Systemic/Behavioral Mechanisms), RC3 (ENU Mutagenesis), RC4 (QTL Analysis), RC5 (Primate Model), RC6 (Schedule-induced Polydypsia and Excessive Alcohol Drinking in Mice), and one Pilot Project, P4 (Massively Parallel QTL Mapping using Microarray).

描述（由申请人提供）： 该应用程序描述了生物分析核心（C＃4），这是五个 综合神经科学计划的分布式核心设施 酒精中毒（INIA）财团，由财团David Lovinger博士领导 范德比尔特大学医学中心（VUMC）协调员，田纳西州纳什维尔。博士 Thomas R. Sutter，是Feinstone Center的生物分析核心的PI（C＃4） 田纳西州孟菲斯大学的基因组研究，分包合同 北卡罗来纳大学，北卡罗来纳州教堂山的莱斯利·莫罗（Leslie Morrow）博士和博士 田纳西大学健康科学中心的威廉·泰勒（William Taylor），田纳西州孟菲斯。 生物分析核心实现了INIA中确定的几个目标 RFA：美国国家酒精滥用与酒精中毒研究所的RFA-AA-01-002： 1）它从 多个研究网站，以提供既建立的方法并创建 酒精研究社区中的新资源，2）此核心带来 从其他地区到酒精领域的成立研究人员，3） 除了提供服务外，生物分析核心是协作的 研究和试点项目组件的研究合作伙伴 参加；协助实验设计，数据收集和分析， 通过生物信息学核心解释和信息传播 （C＃3）最终通过同行​​评审的出版物。通过研究 酒精领域的科学家与研究人员之间的互动 从其他领域，该核心应将新的方法和观点带入 提出的关于关于神经生物学机制的研究的研究 神经适应酒精。生物分析核心（C＃4）服务，并且 与六个研究组件RC1合作（压力高酒精中的细胞机制 相互作用），RC2（全身/行为机制），RC3（ENU 诱变），RC4（QTL分析），RC5（灵长类动物模型），RC6（计划诱导的 小鼠多型和过量饮酒）和一个试点项目P4 （使用微阵列大规模并行QTL映射）。