Acuson Sequoia Ultrasonograph

Acuson Sequoia 超声仪

• 批准号: 6579142
• 负责人: BRIAN D HOIT
• 金额: $ 14.7万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6579142
• 关键词: angiocardioultrasonography; bioimaging /biomedical imaging; biomedical equipment purchase; echocardiography

DESCRIPTION (provided by applicant): The objective of this amended proposal is to acquire a state-of-the-art cardiac ultrasonograph with high spatial and temporal resolution to be used for small animal phenotype analysis. The instrument is used to obtain M-mode, 2-D and Doppler echocardiograms of the heart and great vessels for high-throughput cardiovasculm analysis, and detailed anatomic-physiologic studies in genetically engineered mice and other animal models of cardiovascular disease. The instrument also has the potential for serial imaging of non-cardiac structures, and in this application, investigators propose its use in evaluating polycystic renal disease and granulosa cell tumors. The major users of this instrument include recipients and of NIH peer-reviewed investigator initiated research awards. These biomedical investigators hail from multiple disciplines, including medicine, pediatrics, genetics, physiology and biophysics, pharmacology, anatomy, and pathology. This core of NIH-sponsored investigators from a variety of Departments at CWRU perform studies in rodents and chicks; these investigators have expressed an interest in, and through discussions and subsequent collaborative efforts spanning the past year and one-half, have recognized the critical importance of an echocardiographic evaluation for their research programs.

描述(由申请人提供)： 这一修订方案的目的是获得一种最先进的、高空间和时间分辨率的心脏超声，用于小动物的表型分析。该仪器用于获得心脏和大血管的M型、二维和多普勒超声心动图，用于高通量心血管分析，以及在基因工程小鼠和其他心血管疾病动物模型中进行详细的解剖-生理学研究。该仪器还具有对非心脏结构进行系列成像的潜力，在这一应用中，研究人员建议将其用于评估多囊肾病和颗粒细胞肿瘤。 该工具的主要用户包括NIH同行评议调查员发起的研究奖项的获奖者和获奖者。这些生物医学研究人员来自多个学科，包括医学、儿科学、遗传学、生理学和生物物理学、药理学、解剖学和病理学。这个由美国国立卫生研究院赞助的核心研究人员来自CWRU多个部门，他们在啮齿动物和雏鸟身上进行研究；这些研究人员表示有兴趣，并通过过去一年半的讨论和随后的合作努力，认识到超声心动图评估对他们的研究项目的关键重要性。