Acuson Sequoia Ultrasonograph

描述（由申请人提供）：

DESCRIPTION (provided by applicant): The objective of this amended proposal is to acquire a state-of-the-art cardiac ultrasonograph with high spatial and temporal resolution to be used for small animal phenotype analysis. The instrument is used to obtain M-mode, 2-D and Doppler echocardiograms of the heart and great vessels for high-throughput cardiovasculm analysis, and detailed anatomic-physiologic studies in genetically engineered mice and other animal models of cardiovascular disease. The instrument also has the potential for serial imaging of non-cardiac structures, and in this application, investigators propose its use in evaluating polycystic renal disease and granulosa cell tumors. The major users of this instrument include recipients and of NIH peer-reviewed investigator initiated research awards. These biomedical investigators hail from multiple disciplines, including medicine, pediatrics, genetics, physiology and biophysics, pharmacology, anatomy, and pathology. This core of NIH-sponsored investigators from a variety of Departments at CWRU perform studies in rodents and chicks; these investigators have expressed an interest in, and through discussions and subsequent collaborative efforts spanning the past year and one-half, have recognized the critical importance of an echocardiographic evaluation for their research programs.