NEUROBIOLOGY AND NEUROPSYCHOLOGY OF AGING

描述（来自申请）：该培训计划旨在为博士生和博士后提供衰老神经生物学和神经心理学方面的专门培训。该提案的核心是合并两个长期存在的NIA项目的研究人员的专业知识。一个是在玛丽莲·艾伯特博士的指导下，以麻省总医院（MGH）为中心的人类健康和疾病老化（AG-04953），拟议培训拨款的主任之一；另一个是在波士顿大学医学院（BUSM）为中心的非人类灵长类动物模型（AG-00001）的认知能力下降的神经基础，莫斯博士是另一位主任，也是该学院的Co-PI。培训将侧重于研究领域，包括人类和动物模型正常衰老的神经心理学和神经生物学、与年龄相关的痴呆和神经系统疾病；神经遗传学和神经流行病学；以及细胞和突触超微结构中与年龄相关的变化和其他相关主题的研究。有六名培训师在波士顿大学医学院，三名在哈佛医学院，四名在BUSM附属的退伍军人管理医院。该计划包括深入的课堂教学，动手实验室研究，互动网站，年度实地考察和静修，以及由13名教师调查的一个或多个神经生物学和衰老神经心理学领域的经验。此外，学生和研究员将参加在BUSM和MGH举办的一系列关于老龄化的研讨会，以扩大他们对当代老龄化研究的认识。受训人员还将被鼓励参加教学，为他们担任学术教师职位做准备。针对所有受训人员的课堂指导围绕着团队教授神经生物学和衰老神经心理学入门课程，神经科学课程，以及由哈佛医学院衰老学部举办的衰老夏季系列研讨会。这些课程和研讨会包括讲座、讨论、研究论文评论和实验室演示。

DESCRIPTION (From the application): This training program has been developed to provide predoctoral students and postdoctoral fellows with specific training in the Neurobiology and Neuropsychology of Aging. At the core of this proposal is the merging of the expertise of investigators from two long standing NIA program projects. One is focused on human aging in health and disease (AG-04953) centered at Massachusetts General Hospital (MGH) under the direction of Dr. Marilyn Albert, one of the directors of the proposed training grant, and the other on the neural basis of cognitive decline in a non-human primate model (AG-00001) centered at Boston University School of Medicine (BUSM) of which Dr. Moss, the other director, is Co-PI. The training will focus on areas of research that include the neuropsychology and neurobiology of normal aging in humans and animal models, age-related dementia and neurologic disease; neurogenetics and neuroepidemiology; and studies of age-related changes in cellular and synaptic ultrastructure and other related topics. There are six trainers based at Boston University School of Medicine, three based at Harvard Medical School and four based at BUSM affiliated Veterans Administration Hospitals. The program includes in-depth classroom instruction, hands-on laboratory research, interactive web-site, annual field trip and retreat, and experience in one or more of the areas of the neurobiology and neuropsychology of aging being investigated by the 13 faculty. Additionally, students and fellows will attend a series of seminars on aging at BUSM and at MGH to broaden their knowledge of contemporary aging research. Trainees will also be encouraged to participate in teaching to prepare them for academic faculty positions. Class instruction for all trainees centers around the team taught introductory course in the Neurobiology and Neuropsychology of Aging, a course in Neuroscience, and a summer seminar series on Aging conducted by the Division on Aging at Harvard Medical School. These courses and seminars consist of lectures, discussions, critiques of research paper and laboratory demonstrations.