Memory/Executive Systems in Prefrontal & Temporal Cortex

前额叶的记忆/执行系统

• 批准号: 7152890
• 负责人: Mark Barry Moss
• 金额: $ 52.66万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7152890
• 关键词: Address; Affect; Animals; Area; Behavioral; Bilateral; Brain Injuries; Brain region; Cerebrum; Cognitive; Commissure; Contralateral; Control Animal; Control Groups; Corpus Callosum; Data; Development; Discrimination Learning; Dorsal; Event; Experimental Designs; Functional Magnetic Resonance Imaging; Hippocampal Formation; Hippocampus (Brain); Human; Image; Impairment; Individual; Ipsilateral; Knowledge; Learning; Left; Lesion; Limbic System; Link; Literature; Lobe; Location; Macaca mulatta; Medial; Mediating; Memory; Modeling; Monkeys; Nature; Neurobiology; Outcome; Performance; Phase; Play; Prefrontal Cortex; Preparation; Primates; Prosencephalon; Relative (related person); Role; Sampling; Short-Term Memory; Side; Structure; System; Techniques; Temporal Lobe; Testing; Thinking; Work; anterior commissure; base; behavior test; classical conditioning; cognitive function; dentate gyrus; design; executive function; experience; human subject; insight; memory process; neural circuit; nonhuman primate; relating to nervous system; research study; response; split brain

DESCRIPTION (provided by applicant): This proposal is designed to assess the presence and nature of the relationship between the prefrontal cortex and two medial temporal lobe areas (hippocampal formation and rhinal cortices) in subserving memory and executive function in the primate. In the rhesus monkey, we will use a crossed lesion / split brain technique to isolate and disconnect these two regions of the medial temporal lobe from the prefrontal cortex in order to assess whether there exists a functional interaction between these two brain regions in the performance of memory and executive functions. In order to assess the presence and nature of a functional interaction, it will be necessary to first assess the specific effect of bilateral lesions on each of these three regions. Hence, in the first phase of the study, a cognitive test battery," in which executive function" and "mnemonic" demands within and across tasks will be systematically varied, will be administered to monkeys with bilateral lesions of either the dorsal prefrontal cortex (BFF), the hippocampal formation (BHH), or the rhinal cortices (BRR). In the second phase ("disconnections"), using the same test battery as in the first phase, one experimental group (Group CFHS) will receive a unilateral lesion of the dorsal prefrontal cortex and a contralateral lesion of the hippocampal formation together with a transection of the forebrain commissures. This lesion will disconnect the intact hippocampal formation and prefrontal cortex of the opposite hemispheres. The second experimental group (CFRS) will be prepared with the same unilateral lesion of the dorsal prefrontal cortex but a contralateral lesion of the rhinal cortices with transection of the forebrain commissures. This lesion will disconnect the intact prefrontal cortex from the intact parahippocampal cortices of the opposite hemispheres. In order to assess the effect of these two "disconnections", we will compare their performance to three control groups. The first will be an operated control group (OC) that will also serve as controls for the bilateral lesions in the first phase. The second group (IFHS) will have a unilateral hippocampal formation lesion, an ipsilateral dorsolateral prefrontal lesion, and a transection of the forebrain commissures. This will produce brain damage identical to that in group CFHS, controlling for the total brain damage, but will leave the hippocampal formation and prefrontal cortex on the same side intact and "connected". The third group (IFRS) will have a unilateral lesion of the rhinal cortices along with a unilateral lesion of the dorsolateral prefrontal cortex and transection of the forebrain commissures. This will produce the same degree of brain damage to that in group CFRS, but leave the rhinal and prefrontal cortices on one side intact and "connected".

描述（由申请人提供）：本提案旨在评估前额叶皮层和两个内侧颞叶区域（海马结构和鼻皮质）在灵长类动物的记忆和执行功能中的存在和性质。在恒河猴中，我们将使用交叉损伤/裂脑技术将内侧颞叶的这两个区域与前额叶皮层分离和断开，以评估这两个脑区之间是否存在记忆和执行功能的功能相互作用。为了评估功能相互作用的存在和性质，有必要首先评估双侧病变对这三个区域的具体影响。因此，在研究的第一阶段，将对背侧前额叶皮层（BFF）、海马结构（BHH）或鼻皮质（BRR）双侧病变的猴进行认知成套测试，其中任务内和任务间的“执行功能”和“记忆”需求将系统性变化。在第二阶段（“断开”），使用与第一阶段相同的测试组合，一个实验组（CFHS组）将接受背侧前额叶皮质的单侧损伤和海马结构的对侧损伤以及前脑连合的横断。这种损伤将断开完整的海马结构和相对半球的前额叶皮层。第二个实验组（CFRS）将准备相同的单侧背侧前额叶皮质损伤，但对侧鼻皮质损伤与前脑连合横断。这种损伤会将完整的前额叶皮层与相对半球的完整的海马旁皮层断开。为了评估这两个“断开”的影响，我们将比较他们的表现与三个对照组。第一组为手术对照组（OC），也将作为第一阶段双侧病变的对照组。第二组（IFHS）将有单侧海马结构病变、同侧背外侧前额叶病变和前脑连合横断。这将产生与CFHS组相同的脑损伤，控制总脑损伤，但将使同侧的海马结构和前额叶皮层保持完整和“连接”。第三组（IFRS）将有单侧鼻皮质损伤沿着单侧背外侧前额叶皮质损伤和前脑连合横切。这将产生与CFRS组相同程度的脑损伤，但保留一侧的鼻和前额皮质完整和“连接”。