DEVELOPMENT OF SUBSTANCE USE IN GIRLS

女孩药物滥用的发展

• 批准号: 6699065
• 负责人: ROLF LOEBER
• 金额: $ 29.74万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-15 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6699065
• 关键词: African American; alcoholism /alcohol abuse; behavior disorders; behavioral /social science research tag; caucasian American; child (0-11); disease /disorder proneness /risk; female; human subject; interpersonal relations; longitudinal human study; reproductive development; sex behavior; socioeconomics; substance abuse related behavior; substance abuse related disorder; tobacco abuse

The long-term development of substance use and abuse in girls and women are poorly understood. In at least two ways, females compared to males appear more vulnerable to substance abuse and dependence: a speedier development from onset of use to abuse, and a higher propensity to develop comorbid conditions. In addition, females and males with an early onset of substance use are more likely to become substance abusers. The main goal of the proposed research is to investigate the early phases in this development process. Specifically, we propose to study precursors to the onset of early substance use (i.e., mainly alcohol and tobacco use), the transition to onset of use, and the transition to regular use in an inner-city community sample of 2,484 preadolescent girls. The girls, together with their parent and school teacher, will be assessed yearly and will be followed up over a period of five years. The sample will be made up of approximately 50 percent African-American and 50 percent Caucasian girls. The proposed study will be a substudy linked to and benefitting from the NIMH-funded study on the same girls, which has as its main object the study of the development of antisocial and delinquent behavior. The present proposal has three foci: 1). To identify the developmental precursors to the onset and regular use of substances; 2). To examine behavior problems which interact with early substance use; and 3) To elucidate the risk and protective factors predictive of the precursors of early substance use and predictive of the early use. The proposed study will be the foundation upon which follow-ups beyond the current five-year period can be built in order to better understand the long-term antecedents, risk and protective factors for substance abuse and dependence in females.

人们对女孩和妇女药物使用和滥用的长期发展知之甚少。至少在两个方面，与男性相比，女性似乎更容易受到药物滥用和依赖的影响：从开始使用到滥用的发展速度更快，以及更容易出现合并症。此外，早期开始使用药物的女性和男性更有可能成为药物滥用者。拟议研究的主要目标是调查这一发展过程的早期阶段。具体来说，我们建议研究2484名内城区青春期前女孩样本中早期物质使用（即主要是酒精和烟草使用）开始的前兆，向开始使用的过渡，以及向常规使用的过渡。这些女孩，连同她们的父母和学校老师，将每年接受评估，并将在五年内进行随访。样本将由大约50%的非裔美国女孩和50%的高加索女孩组成。拟议的研究将是与nimh资助的对同一群女孩的研究相关联并受益的子研究，该研究的主要目标是研究反社会和犯罪行为的发展。目前的建议有三个重点：1)。查明开始使用和经常使用药物的发育前体；2)。检查与早期药物使用相关的行为问题；3)阐明预测早期物质使用前体和预测早期物质使用的危险因素和保护因素。拟议的研究将成为今后五年后续行动的基础，以便更好地了解妇女药物滥用和依赖的长期前因、风险和保护因素。