Development of Substance Use in Girls

女孩药物滥用的发展

• 批准号: 7758795
• 负责人: ROLF LOEBER
• 金额: $ 35.46万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-15 至 2011-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7758795
• 关键词: Address; Adolescence; Affect; African American; Age; Aggressive behavior; Alcohol abuse; Alcohol or Other Drugs use; Attitude; Behavior; Behavior Control; Behavioral; Caucasians; Caucasoid Race; Child; Childhood; Cognition; Cognitive; Communities; Comorbidity; Conduct Disorder; Conflict (Psychology); Data; Dependence; Development; Distal; Emotional; Epidemiologic Studies; Ethnic Origin; Ethnic group; Expectancy; Family; Female; Funding; Future; Gender; Generic Drugs; Goals; Individual; Individual Differences; Investigation; Knowledge; Link; Measures; Mental Depression; Mental Health; National Institute of Drug Abuse; National Institute of Mental Health; Neighborhoods; Pharmaceutical Preparations; Phase; Population; Post-Traumatic Stress Disorders; Prevention; Probability; Problem behavior; Psychopathology; Race; Request for Proposals; Research; Risk; Rolfing; Sampling; Sexual abuse; Staging; Substance Use Disorder; Substance abuse problem; Time; Tobacco use; United States; Urban Population; anti social; cohort; cost; data management; design; early adolescence; early onset substance use; follow up assessment; girls; high risk; high risk sexual behavior; inattention; male; neglect; peer; population based; pubertal timing; racial and ethnic; teacher

The long-term development of female substance use, substance-related problems, and substance use disorders (SUDs) is poorly understood. In at least two ways, females appear more vulnerable to substance abuse and dependence compared to males: they demonstrate more rapid development from onset of use to SUD, and a higher propensity to develop comorbid psychopathology. In addition, early onset of substance use carries a higher risk of developing an SUD among females compared with males. The main goal of the proposed research is to investigate the early phases in the development towards frequent substance use, substance-related problems, and SUD. This proposal describes a substudy to the NIMH-funded Pittsburgh Girls Study (N = 2,451; 52% African-American, 41% Caucasian), an investigation of the development of antisocial behavior and delinquency in four age cohorts of girls, initially assessed at ages 5 to 8. The main study is now in its fifth yearly assessment (ages 9 to 12), and will continue for another 4 years. The proposed study requests a continuation of earlier funding by NIDA, which supported examination of the precursors and explanatory factors associated with girls' early substance use. The proposed research, through five yearly follow-up assessments of the child, the main caretaker, and teachers, extends this line of inquiry into the developmental period from age 10 to 17, when we expect that girls' substance use, substance- related problems, and comorbid conditions will increase. The aims of the proposed research are to: (1) describe developmental sequences of substance use by girls during the transition from childhood into adolescence within and across substances; (2) examine developmental sequences of substance use by girls in conjunction with the developmental course of comorbid conditions, especially psychopathology and other behavior problems; and (3) determine proximal and distal risk and protective factors (both generic and female-specific) for different developmental sequences of substance use by girls. These three aims, in conjunction with the data on early substance use and attitudes already collected, will link childhood factors to substance use during adolescence. The Pittsburgh Girl Study is one of the very few studies in the USA that can examine these relationships from childhood through adolescence.

女性物质使用的长期发展、物质相关问题以及 人们对物质使用障碍（SUD）知之甚少。女性至少以两种方式出现 与男性相比，他们更容易受到药物滥用和依赖：他们证明 从开始使用到 SUD 的发展更加迅速，并且发展的倾向更高 共病精神病理学。此外，过早开始使用药物会带来更高的风险 与男性相比，女性发展出 SUD。拟议的主要目标 研究的目的是调查频繁使用药物的发展的早期阶段， 物质相关问题和 SUD。该提案描述了 NIMH 资助的一项子研究 匹兹堡女孩研究（N = 2,451；52% 非洲裔美国人，41% 白种人），一项针对 最初，四个年龄段的女孩出现反社会行为和犯罪行为 在 5 至 8 岁之间进行评估。主要研究目前正在进行第五次年度评估（9 至 12 岁），并且 将持续另外4年。拟议的研究要求继续早期的资助 NIDA 支持对前体和相关解释因素的审查 与女孩早期物质使用有关。拟议的研究，通过五年的随访 对儿童、主要看护者和教师的评估，将这一探究范围延伸到 从 10 岁到 17 岁的发育期，我们预计女孩的物质使用、物质- 相关问题和合并症将会增加。拟议研究的目的是 目的：(1) 描述女孩在从 物质内部和物质之间的童年到青春期； (2)检查发育情况 女孩物质使用顺序与共病发展过程的关系 状况，尤其是精神病理学和其他行为问题； (3) 确定 不同人群的近端和远端风险和保护因素（通用的和女性特有的） 女孩物质使用的发展顺序。这三个目标与 已收集的有关早期药物使用和态度的数据将把童年因素与 青春期期间的物质使用。匹兹堡女孩研究是极少数的研究之一 美国可以检查从童年到青春期的这些关系。