In vitro Investigation Assessing Erosive and Abrasive Toothwear Challenges on Natural Human Enamel

评估天然人类牙釉质侵蚀和磨损牙磨损挑战的体外研究

• 批准号: 2382941
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2382941
• 关键词: vitro; Investigation; Assessing; Erosive; Abrasive

Given that the history of the literature for tooth wear has been around polished enamel and now with the advices in the methods in analysing non uniform curved surfaces can we investigate the interplay of erosion and abrasion on natural enamel along with this explore the remineralising and protective agents available with consideration to their modifications.To start with - Assess abrasion parameters and their impact on erosive tooth wear for polished enamel - given the majority of the research has previously focused on polished enamel can I reproduce some of the results to enhance my experimental ability Following this compare abrasion parameters on the impact of erosive tooth wear on natural enamelMethodology will see the exploration of both erosion, abrasion and erosion and abrasion to start with and use synthetic salivaSamples will be prepared by sectioning - embedding - polishing - sample to confirm flatness - erosive/abrasive challenges - analysis the analysis to start with will be assent of step height sessions via a profilometerwe will also look to explore micro hardness and other analytic methodsthe above methodology will be for study 1 in the thesisStudy 2 has moved to natural curved surfaces further studies are now both exploring the uses of silicone to take the wear model to a possible clinical trial as well as exploring the use of agents such as fluoride to determine use for wear prevention

考虑到关于牙齿磨损的文献的历史是围绕抛光牙釉质的，现在随着分析非均匀曲面的方法的建议，我们能否调查侵蚀和磨损对自然牙釉质的相互作用，同时探索考虑它们的修改的可用的再矿化和保护剂。首先-评估磨损参数及其对抛光牙釉质的腐蚀磨损的影响-鉴于之前的大部分研究都集中在抛光牙釉质上，我可以重现一些结果来增强我的实验能力吗？在比较磨损参数关于侵蚀牙磨损对自然牙釉质的影响之后，方法论将看到对两者的探索，磨损、侵蚀和磨损从人工唾液开始和使用将通过切片-包埋-抛光-样品以确认平整度-腐蚀性/磨损性挑战-分析来制备样品首先通过轮廓仪对台阶高度进行分析我们还将寻求探索显微硬度和其他分析方法上述方法将用于理论研究1研究2已转移到自然曲面进一步研究现在正在探索硅胶的用途以将磨损模型应用于可能的临床试验以及探索使用诸如氟化物等试剂来确定用于预防磨损的用途