Determination of benchmarking parameters for assessing the mechanical robustness of articular cartilage: a joint mathematical and experimental investigation

确定评估关节软骨机械鲁棒性的基准参数：联合数学和实验研究

• 批准号: DP0453210
• 负责人: Em/Prof Donald McElwain
• 金额: $ 19.2万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-07-31 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0453210
• 关键词: Determination; benchmarking; parameters; assessing; mechanical

Osteoarthritis associated with the deterioration of the articular cartilage affects about 12% of Australian adults. This project will use an integrated approach combining novel mathematical modelling and an extensive experimental program to establish critical mechanical parameters, in particular, the fracture toughness of articular cartilage and will incorporate the unique structure of the dissimilar layers in articular cartilage. It will be used to study how these resist the propagation of an initiated crack and will offer significant insight into the desirable fracture properties of any replacement material for articular cartilage and will provide a basis for assessing replacement biomaterials.

与关节软骨退化相关的骨关节炎影响约12%的澳大利亚成年人。该项目将使用一种综合方法，结合新颖的数学建模和广泛的实验程序，以建立关键的机械参数，特别是关节软骨的断裂韧性，并将结合关节软骨中不同层的独特结构。它将被用来研究这些如何抵抗初始裂纹的传播，并将提供显着的洞察任何关节软骨替代材料的理想的断裂性能，并将提供评估替代生物材料的基础。