Determination of benchmarking parameters for assessing the mechanical robustness of articular cartilage: a joint mathematical and experimental investigation

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Osteoarthritis associated with the deterioration of the articular cartilage affects about 12% of Australian adults. This project will use an integrated approach combining novel mathematical modelling and an extensive experimental program to establish critical mechanical parameters, in particular, the fracture toughness of articular cartilage and will incorporate the unique structure of the dissimilar layers in articular cartilage. It will be used to study how these resist the propagation of an initiated crack and will offer significant insight into the desirable fracture properties of any replacement material for articular cartilage and will provide a basis for assessing replacement biomaterials.