Core--Utah Population Database

核心--犹他州人口数据库

• 批准号: 6990234
• 负责人: GERALDINE P MINEAU
• 金额: $ 1.85万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-09 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6990234
• 关键词: biomedical facility; cancer information system; neoplasm /cancer; neoplasm /cancer genetics

The Utah Population Database (UPDB) is a University of Utah research resource that supports about 45 research projects and provides access to about 7.1 million records. It is a rich source of information for genetic, epidemiological, demographic and public health studies. The critical component is an extensive set of family histories, whose family members are linked to medical information. In addition to genealogy and fandly history data, UPDB maintains information on all cancers diagnosed in Utah and Idaho, as well as all Utah death certificates. Research studies typically incorporate the family or pedigree structure as part of the research design. These data allow the identification of familial clustering of cancer. The UPDB is the only such database in the US and one of few such resources in the world. All projects require IRB approval. In addition, the Utah Resource for Genetic and Epidemiologic Research (RGE) administers access to the UPDB files through a review process. The aim of this core is to support biomedical and health-related research with an emphasis on cancer genetics and survival. The goals of the UPDB core are to: 1) Maintain an infrastructure for research by linking cancer, birth, death and driver license data to UPDB, 2) Maintain pedigree infrastructure and analysis tools (e.g. pedigree drawing tools), 3) Provide access to UPDB to support cancer research projects, 4) Update IIPDB information annually, thus providing research projects follow-up information (e.g., deaths, cancer recurrence). These activities require up-to-date resources that are beyond the scope of any single research project. This resource makes available large datasets and multi-generation pedigrees while protecting the privacy of individual-level data in UPDB. Within the next two years, several projects will be completed that refine analysis tools used to analyze pedigrees and that expand the scope of medical records available to users of UPDB.

犹他州人口数据库 (UPDB) 是犹他大学的一个研究资源，支持约 45 个研究项目并提供约 710 万条记录的访问。它是遗传、流行病学、人口和公共卫生研究的丰富信息来源。关键的组成部分是一套广泛的家族史，其家庭成员与医疗信息相关联。除了家谱和丰富的历史数据外，UPDB 还维护犹他州和爱达荷州诊断的所有癌症的信息，以及犹他州的所有死亡证明。研究通常将家庭或谱系结构纳入研究设计的一部分。这些数据可以识别癌症的家族聚集性。 UPDB 是美国唯一的此类数据库，也是世界上为数不多的此类资源之一。所有项目都需要 IRB 批准。此外，犹他州遗传和流行病学研究资源 (RGE) 通过审查流程管理对 UPDB 文件的访问。该核心的目标是支持生物医学和健康相关研究，重点是癌症遗传学和生存。 UPDB 核心的目标是： 1) 通过将癌症、出生、死亡和驾驶执照数据链接到 UPDB 来维护研究基础设施， 2）维护谱系基础设施和分析工具（例如谱系绘图工具）， 3) 提供对 UPDB 的访问以支持癌症研究项目， 4）每年更新IIPDB信息，从而提供研究项目的后续信息（例如死亡、癌症复发）。 这些活动需要最新的资源，超出了任何单个研究项目的范围。该资源提供大型数据集和多代谱系，同时保护 UPDB 中个人级数据的隐私。未来两年内，将完成多个项目，完善用于分析谱系的分析工具，并扩大 UPDB 用户可用的医疗记录范围。