Core--Utah Population Database

犹他州人口数据库(UPDB)是犹他大学的研究资源，支持约45个研究项目，并提供约710万条记录。它是遗传学、流行病学、人口学和公共卫生研究的丰富信息来源。关键的组成部分是一套广泛的家族史，其家庭成员与医疗信息有关。除了家谱和花哨的历史数据，UPDB还维护犹他州和爱达荷州诊断出的所有癌症的信息，以及犹他州的所有死亡证明。研究通常将家庭或谱系结构作为研究设计的一部分。这些数据可以识别癌症的家族聚集性。UPDB是美国唯一的此类数据库，也是世界上为数不多的此类资源之一。所有项目都需要IRB的批准。此外，犹他州遗传和流行病学研究资源(RGE)通过审查程序管理对UPDB文件的访问。这个核心的目的是支持生物医学和与健康相关的研究，重点是癌症遗传学和存活率。UPDB核心的目标是： 1)通过将癌症、出生、死亡和驾驶执照数据与UPDB联系起来，维护研究基础设施， 2)维护谱系基础设施和分析工具(例如谱系绘制工具)； 3)提供进入UPDB的渠道，以支持癌症研究项目， 4)每年更新IIPDB信息，从而提供研究项目的后续信息(如死亡、癌症复发)。 这些活动所需的最新资源超出了任何单一研究项目的范围。这一资源提供了大型数据集和多代谱系，同时保护了UPDB中个人级别数据的隐私。在接下来的两年内，将完成几个项目，完善用于分析家谱的分析工具，并扩大UPDB用户可以获得的医疗记录的范围。

The Utah Population Database (UPDB) is a University of Utah research resource that supports about 45 research projects and provides access to about 7.1 million records. It is a rich source of information for genetic, epidemiological, demographic and public health studies. The critical component is an extensive set of family histories, whose family members are linked to medical information. In addition to genealogy and fandly history data, UPDB maintains information on all cancers diagnosed in Utah and Idaho, as well as all Utah death certificates. Research studies typically incorporate the family or pedigree structure as part of the research design. These data allow the identification of familial clustering of cancer. The UPDB is the only such database in the US and one of few such resources in the world. All projects require IRB approval. In addition, the Utah Resource for Genetic and Epidemiologic Research (RGE) administers access to the UPDB files through a review process. The aim of this core is to support biomedical and health-related research with an emphasis on cancer genetics and survival. The goals of the UPDB core are to: 1) Maintain an infrastructure for research by linking cancer, birth, death and driver license data to UPDB, 2) Maintain pedigree infrastructure and analysis tools (e.g. pedigree drawing tools), 3) Provide access to UPDB to support cancer research projects, 4) Update IIPDB information annually, thus providing research projects follow-up information (e.g., deaths, cancer recurrence). These activities require up-to-date resources that are beyond the scope of any single research project. This resource makes available large datasets and multi-generation pedigrees while protecting the privacy of individual-level data in UPDB. Within the next two years, several projects will be completed that refine analysis tools used to analyze pedigrees and that expand the scope of medical records available to users of UPDB.