JOHNS HOPKINS CENTER FOR AIDS RESEARCH

描述(改编自申请)：本申请建议 在约翰霍普金斯大学(JHU)重新建立CFAR，与 在JHU促进合作和创新的艾滋病研究的目标。对这件事 最后，拟议的CFAR将支持从 特征明确的患者群体(临床核心)；试点项目计划 这将增加富有成效的调查人员追查 高风险、高影响力的想法(开发核心)；关键服务核心设施 (流式细胞术和细胞分选核心，单抗核心)；以及 旨在传播关键科学知识的集中管理行动 信息和增加艾滋病人之间在智力上富有成效的接触 研究人员(行政核心)。行政核心将包括 JHU和Will艾滋病毒/艾滋病研究各学科的代表 定期审查CFAR支持的所有活动的成本效益，如 与CFAR可以支持的其他核心和程序相比。最初， 将强调HIV感染的四个关键方面：1)发病机制，2) 潜伏的HIV感染，3)免疫恢复，4)预防。总体而言， CFAR的具体目标将是在 研究人员，促进创新和协作研究，带来新的 调查艾滋病毒/艾滋病研究，提高艾滋病毒/艾滋病的知名度 约翰霍普金斯大学的研究。

DESCRIPTION (Adapted from application): This application proposes to re-establish a CFAR at Johns Hopkins University (JHU), with the goal of fostering collaborative and innovative AIDS research at JHU. To this end, the proposed CFAR will support collection of clinical specimens from a well-characterized patient population (Clinical Core); a pilot project program that would increase the ability of productive investigators to pursue high-risk, high impact ideas (Developmental Core); key service Core facilities (Flow Cytometry and Cell Sorting Core, Monoclonal Antibody Core); and centralized administrative operations designed to disseminate key scientific information and increase intellectually fruitful contact among AIDS researchers (Administrative Core). The Administrative Core will include representatives of all disciplines of HIV/AIDS research at JHU and will regularly review the cost-effectiveness of all CFAR-supported activities, as compared to other Cores and programs that the CFAR could support. Initially, four critical aspects of HIV infection will be emphasized: 1) pathogenesis, 2) latent HIV infection, 3) immune restoration, and 4) prevention. Overall, the specific aims of the CFAR will be to disseminate scientific information among investigators, foster innovative and collaborative research, bring new investigators into HIV/AIDS research, and increase the profile of HIV/AIDS research at Johns Hopkins University.