CANCER CENTER SUPPORT GRANT

描述（由申请人提供）：本申请代表伯纳姆研究所癌症中心的癌症中心支持补助金（CCSG）的竞争性更新。自1981年以来，癌症中心一直是国家癌症研究所CCSG支持的接受者。伯纳姆研究所是一个独立的非营利组织，致力于癌症和其他退行性疾病的基础研究。自上次CCSG的竞争性更新以来，该研究所癌症中心的成员从34名研究人员增加到目前的54名主要、次要和辅助成员。此外，该研究所现在包括一个较小的神经科学和衰老研究中心。然而，到目前为止，与癌症相关的研究仍然是伯纳姆研究所的主要科学重点。癌症中心下设6个科研项目：(1)细胞粘附与细胞外基质；(2)糖生物学;(3)肿瘤发育生物学；(4)癌症遗传学与表观遗传学；(5)信号转导研究；(6)细胞凋亡和细胞死亡。在过去的资助期内，癌症中心进一步提高了其在细胞基质相互作用、糖生物学和细胞死亡机制领域的科学地位。一些新的共享资源已经开发出来（例如，高通量细胞分析设备），11名新的全职教师已经被招募到癌症中心项目作为主要或次要成员。

DESCRIPTION (provided by applicant): The present application represents the competitive renewal of the Cancer Center Support Grant (CCSG) for The Burnham Institute's Cancer Center. The Cancer Center has been a recipient of CCSG support from the National Cancer Institute since 1981. The Burnham Institute is an independent, non-profit organization dedicated to basic research related to cancer and other degenerative diseases. Since the last competitive renewal of the CCSG, the Institute's Cancer Center membership has increased from 34 investigators to its current total of 54 primary, secondary and adjunct members. In addition, the Institute now contains a smaller Neurosciences and Aging Research Center. However, cancer-related research remains by far the predominant scientific focus of The Burnham Institute. The Cancer Center contains 6 scientific programs: (1) Cell Adhesion and Extracellular Matrix; (2) Glycobiology; (3) Oncodevelopmental Biology; (4) Cancer Genetics and Epigenetics; (5) Signal Transduction Research; and (6) Apoptosis and Cell Death. During the past funding period, the Cancer Center has further enhanced its position of scientific prominence in the areas of cell-matrix interactions, glycobiology and cell death mechanisms. Several new shared resources have been developed (e.g., the High-throughput Cell Analysis Facility), and 11 new, full-time faculty members have been recruited into Cancer Center Programs as primary or secondary members. Developing areas of research strength include mitogenic and stress-induced signal transduction, genome surveillance, and genetic instability. During the next funding period, our overarching plan for Center development is to integrate chemical biology into the existing blend of cell biology and structural biology that characterizes each of our programs. Our goals are to encourage the use of small molecules as probes for studies of normal and cancer cell biology, and to develop lead compounds that might serve as candidates for further development as anticancer drugs. To accomplish these objectives, the Cancer Center will facilitate research activities related to chemical library screening, high-throughput cell analysis, gene microarray analysis, and proteomics. In addition, we plan to build additional expertise in chemistry and chemical biology through the recruitment of new faculty into the Center. Our overall objective is to forge more direct connections between our discovery-based research and the development of novel strategies for cancer prevention and therapy.