Center of Excellence in Chemical Methodologies and Libr*

描述(申请人提供)：建议建立一个化学方法论和图书馆设计中心。该中心的科学重点将是创新组合化学的发展。贯穿始终的重点是能够导致包含以下分子的文库的技术：(1)利用支架设计的新原则(特别是将多个支架核心结合到给定的文库中)和(2)基于合理的药物设计原则可能具有药理活性。这项工作将通过侧重于相转移和提纯的新方法以及有机金属化学的其他项目来促进。 拟建的中心将包括三个核心(管理、合成和图书馆设计与分析)和下列主题科学工作：(1)组合化学的新相转移方法，(2)生物仿生，(3)有机金属组合化学，(4)天然产物和特权结构。 堪萨斯大学、堪萨斯州立大学和爱荷华州立大学的科学家将指导这项拟议的工作。将通过在位于堪萨斯州劳伦斯的堪萨斯大学新收购的生命科学研究实验室(LSRL)建立一个组合化学研究中央实验室来促进这项工作。该实验室设施毗邻一个高通量筛选实验室， 其他生命科学研究人员在东口生物科学中心，这将促进生物 合作。

DESCRIPTION (provided by applicant): A Center for Chemical Methodology and Library Design is proposed. The scientific focus of this Center will be the development of innovative combinatorial chemistry. The focus throughout is on techniques capable of leading to libraries containing molecules that (1) that utilize new principles of scaffold design (and especially the incorporation of multiple scaffold cores into a given library) and (2) are likely to have pharmacological activity based on sound drug design principles. This work will be facilitated through additional projects that focus on novel methods for phase trafficking and purification as well as organometallic chemistry. The proposed center will comprise three cores (administration, synthesis, and library design and analysis) and the following thematic scientific efforts: (1) New Phase-Trafficking Methodologies for Combinatorial Chemistry, (2) Biomimetics, (3) Organometallic Combinatorial Chemistry, and (4) Natural Products and Privileged Structures. Scientists at the University of Kansas, Kansas State University, and Iowa State University will direct the proposed work. It will be facilitated through the establishment of a centralized laboratory for combinatorial chemistry research in the newly acquired Life Sciences Research Laboratory (LSRL) at the University of Kansas in Lawrence, KS. The laboratory facility is adjacent to a high-throughput screening laboratory and other life science researchers in the Higuchi Biosciences Center, which will facilitate biological collaborations.