Center of Excellence in Chemical Methodologies and Libr*

描述（申请者提供）：拟设立化学方法学与图书馆设计中心。该中心的科学重点将是创新组合化学的发展。整个过程的重点是能够产生包含分子库的技术，这些分子库：(1)利用新的支架设计原则（特别是将多个支架核心合并到给定的文库中），(2)可能具有基于合理药物设计原则的药理活性。这项工作将通过侧重于相输送和净化以及有机金属化学的新方法的其他项目来促进。

DESCRIPTION (provided by applicant): A Center for Chemical Methodology and Library Design is proposed. The scientific focus of this Center will be the development of innovative combinatorial chemistry. The focus throughout is on techniques capable of leading to libraries containing molecules that (1) that utilize new principles of scaffold design (and especially the incorporation of multiple scaffold cores into a given library) and (2) are likely to have pharmacological activity based on sound drug design principles. This work will be facilitated through additional projects that focus on novel methods for phase trafficking and purification as well as organometallic chemistry. The proposed center will comprise three cores (administration, synthesis, and library design and analysis) and the following thematic scientific efforts: (1) New Phase-Trafficking Methodologies for Combinatorial Chemistry, (2) Biomimetics, (3) Organometallic Combinatorial Chemistry, and (4) Natural Products and Privileged Structures. Scientists at the University of Kansas, Kansas State University, and Iowa State University will direct the proposed work. It will be facilitated through the establishment of a centralized laboratory for combinatorial chemistry research in the newly acquired Life Sciences Research Laboratory (LSRL) at the University of Kansas in Lawrence, KS. The laboratory facility is adjacent to a high-throughput screening laboratory and other life science researchers in the Higuchi Biosciences Center, which will facilitate biological collaborations.