UNC Chemical Biology Interface Training Program

北卡罗来纳大学化学生物学界面培训计划

• 批准号: 10415825
• 负责人: Jeffrey Aube
• 金额: $ 26.4万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10415825
• 关键词: Biology; Chemicals; Training Programs

ABSTRACT We propose to establish a Chemistry–Biology Interface (CBI) Training Program that will enable trainees at the University of North Carolina at Chapel Hill (UNC) to obtain the breadth of scientific training essential for modern, mechanistically informed chemical biology. This program draws from two historically successful programs at UNC: the Division of Chemical Biology and Medicinal Chemistry (CBMC) in the UNC Eshelman School of Pharmacy, and the Biological and Organic Chemistry Divisions in the UNC Department of Chemistry (College of Arts and Sciences). These two units have a strong and continuing tradition of collaboration, common coursework, and a shared seminar series. Although UNC has a highly regarded scientific tradition, there is no chemistry-oriented NIH training program on the UNC campus. The proposed program will bring together 25 established researchers who encompass the breadth of chemical biology, ranging from analytical bioanalysis to protein structure/function to medicinal chemistry/drug design. In addition, three promising junior faculty members will join the program as “mentored mentors”, working closely with senior colleagues as they continue to establish their programs. The program leaders, one from CBMC and one from the Department of Chemistry, are accomplished senior faculty with mentoring and administrative experience; they will provide program guidance with input from an internal steering committee and a distinguished group of external advisors. Students will be recruited from the two primary units and from a UNC umbrella biological/biomedical sciences program that has shown remarkable success in recruiting outstanding and diverse graduate students to the campus. The training program includes (1) common coursework that establishes the basis for research at the chemistry–biology interface, including responsible conduct of research and rigor/reproducibility training, (2) biweekly meetings that alternate between a journal club and a smaller discussion group focused on individual learning and professional development, (3) an program retreat that will be held before the fall semester, providing orientation and early formal training in rigor and reproducibility, and (4) a trainee-organized symposium that will become a major annual event at UNC. Work at the chemistry–biology interface has become increasingly relevant as our understanding of biology has required more molecular insights. Accordingly, the activities of the proposed program will capitalize on the diverse expertise in CBMC and Chemistry, and the extensive educational and research resources that are available at this internationally recognized institution. This program will provide trainees with a superior education from the perspective of depth and breadth, and develop well-trained PhD scholars at the interface of chemistry and biology who will play a critical role in the biomedical sciences across academia and industry.

抽象的 我们建议建立一个化学-生物界面（CBI）培训计划，使学员能够 北卡罗来纳大学教堂山分校 (UNC) 获得广泛的科学培训至关重要 现代的、机械化的化学生物学。该计划借鉴了两个历史上成功的计划 北卡罗来纳大学的项目：北卡罗来纳大学埃谢尔曼分校的化学生物学和药物化学部门（CBMC） 药学院以及北卡罗来纳大学化学系生物和有机化学系 （艺术与科学学院）。这两个单位有着强大而持续的合作传统， 共同的课程作业和共享的研讨会系列。尽管北卡罗来纳大学拥有备受推崇的科学传统， 北卡罗来纳大学校园内没有面向化学的 NIH 培训项目。拟议的计划将带来 共有 25 名知名研究人员，涵盖化学生物学的广度，从分析到 生物分析到蛋白质结构/功能到药物化学/药物设计。此外，三位有前途的青年 教职员工将以“指导导师”的身份加入该计划，与资深同事密切合作 继续制定他们的计划。项目负责人，一名来自 CBMC，一名来自教育部 化学，是具有指导和管理经验的资深教师；他们将提供 计划指导由内部指导委员会和杰出的外部小组提供意见 顾问。学生将从两个主要单位和北卡罗来纳大学生物/生物医学伞系招募 科学项目在招收优秀且多样化的研究生方面取得了显著成功 到校园。培训计划包括 (1) 为研究奠定基础的通用课程 在化学-生物学界面，包括负责任的研究行为和严格/可重复性培训， (2) 每两周一次的会议，在期刊俱乐部和较小的讨论小组之间轮流举行，重点关注 个人学习和专业发展，（3）秋季前举行的计划务虚会 学期，提供严格性和可重复性方面的指导和早期正式培训，以及（4）由学员组织 研讨会将成为北卡罗来纳大学的一项重大年度活动。化学-生物界面方面的工作 随着我们对生物学的理解需要更多的分子洞察力，它变得越来越重要。 因此，拟议计划的活动将利用 CBMC 和 化学以及国际上提供的广泛的教育和研究资源 认可的机构。该计划将从以下角度为学员提供优质教育： 深度和广度，并培养训练有素的化学和生物学交叉领域的博士学者，他们将 在学术界和工业界的生物医学科学中发挥着关键作用。