Center of Excellence in Chemical Methodologies and Libr*

描述（由申请人提供）：化学方法和库设计中心的建议。该中心的科学重点将是创新组合化学的发展。全文的重点是能够产生含有分子的文库的技术，所述分子（1）利用支架设计的新原理（并且特别是将多个支架核心并入给定文库中）和（2）基于合理的药物设计原理可能具有药理学活性。这项工作将通过更多的项目，重点放在新的方法相贩运和纯化以及有机金属化学促进。 拟议的中心将包括三个核心（管理，合成和库设计和分析）和以下主题科学工作：（1）组合化学的新阶段贩运方法，（2）仿生学，（3）有机组合化学，（4）天然产物和嵌入式结构。 堪萨斯大学、堪萨斯州立大学和爱荷华州州立大学的科学家将指导这项拟议中的工作。这将通过在堪萨斯州劳伦斯市的堪萨斯大学新收购的生命科学研究实验室（LSRL）建立一个集中的组合化学研究实验室来促进。实验室设施毗邻高通量筛选实验室， Higuchi生物科学中心的其他生命科学研究人员，这将促进生物学 合作。

DESCRIPTION (provided by applicant): A Center for Chemical Methodology and Library Design is proposed. The scientific focus of this Center will be the development of innovative combinatorial chemistry. The focus throughout is on techniques capable of leading to libraries containing molecules that (1) that utilize new principles of scaffold design (and especially the incorporation of multiple scaffold cores into a given library) and (2) are likely to have pharmacological activity based on sound drug design principles. This work will be facilitated through additional projects that focus on novel methods for phase trafficking and purification as well as organometallic chemistry. The proposed center will comprise three cores (administration, synthesis, and library design and analysis) and the following thematic scientific efforts: (1) New Phase-Trafficking Methodologies for Combinatorial Chemistry, (2) Biomimetics, (3) Organometallic Combinatorial Chemistry, and (4) Natural Products and Privileged Structures. Scientists at the University of Kansas, Kansas State University, and Iowa State University will direct the proposed work. It will be facilitated through the establishment of a centralized laboratory for combinatorial chemistry research in the newly acquired Life Sciences Research Laboratory (LSRL) at the University of Kansas in Lawrence, KS. The laboratory facility is adjacent to a high-throughput screening laboratory and other life science researchers in the Higuchi Biosciences Center, which will facilitate biological collaborations.