Core--Genomics

基因组学核心设施将提供获得更高水平的生物信息学能力，以进行多序列比对、系统发育推断或种群生物学分析。贝保罗比较分子生物学和进化中心的教职员工和生物信息学工作人员在纯统计学、基因组组装、天体物理建模、基因表达、系统发育、信息管理、数据获取管道和数据库方面拥有丰富的专业知识。这种专门知识与我们先进的计算资源相结合，将满足伍兹霍尔海洋和人类健康中心支持的每个项目的预期需求。Sogin博士将与安德鲁·麦克阿瑟博士协商，就使用适当的计算机算法向个人项目PI提供建议。一般的方法是使用CLUSTALX{JeanMougin，1998#27}对大型数据集进行比对。可以使用手动校正(间隙位置的交互改变)来改进对齐。系统发育分析通常只考虑对比较位点同源性有信心的区域。

The Genomics Core Facility will provide access to higher-level bioinformatics capabilities for multiple sequence alignment, and phylogenetic inference or population biology analyses. The faculty and bioinformatics staff of the Bay Paul Center for Comparative Molecular Biology and Evolution has considerable expertise in pure statistics, genome assembly, astrophysical modeling, gene expression, phylogenetics, information management, data acquisition pipelines, and data basing. The combination of this expertise with our advanced computational resources will meet anticipated needs for each of the projects supported by The Woods Hole Center for Oceans and Human Health. Dr. Sogin in consultation with Dr. Andrew McArthur, will advise PIs of individual projects on the use of appropriate computer algorithms. The general approach will be to use CLUSTALX {Jeanmougin, 1998 #27} for the alignment of large data sets. Manual corrections (interactive changes in positioning of gaps) may be used to improve the alignments. The phylogenetic analyses will normally only consider regions where there is confidence in homology of the compared sites.