Analysis of Heart Rate Variability in Sleep Apnea

描述（申请人提供）：睡眠呼吸障碍（SDB）是儿童和成人心血管和神经认知疾病的常见和严重原因。夜间多导睡眠图是目前临床诊断某些形式的呼吸障碍的黄金标准，但这种程序昂贵、繁琐且不易获得。最近，越来越多的人认识到，使用非线性动力学理论进行心率变异性分析可能为阻塞性睡眠呼吸暂停综合征（OSAS）提供有用的、无创的标志物。这个探索性（R21）项目将研究心脏混沌作为成人和儿童OSAS患者心脏自主神经张力变化的新测量方法的可行性和潜在优势。在NHLBI创新研究资助计划（PA-03-015）的指导下，麻省理工学院、布里格姆妇女医院和波士顿儿童医院建立了一个三方联盟，旨在提供必要的生物信息学/临床专业知识和相关临床数据库，以便使用最先进的分析技术对OSAS患者的心率变异性进行系统评估。该结果将定义OSAS患者心率变异性的非线性动力学，为未来开发可靠的、无创的儿童和成人OSAS动态筛查试验奠定基础。

DESCRIPTION (provided by applicant): Sleep-disordered breathing (SDB) is a common and serious cause of cardiovascular and neurocognitive morbidity in children and adults. Overnight polysomnography is presently the gold standard for the clinical diagnosis of certain forms of obstructed breathing, but such procedures are costly, cumbersome and not readily available. Recently, there has been increasing recognition that heart rate variability analysis using nonlinear dynamics theory may provide a useful, noninvasive marker for the obstructive sleep apnea syndrome (OSAS). This exploratory (R21) project will examine the feasibility and potential advantages of heartrate chaos as a novel measure of the changes in cardiac autonomic tone in adults and children with OSAS. Under the guidelines of the NHLBI Innovative Research Grant Program (PA-03-015), a three-way consortium between Massachusetts Institute of Technology, Brigham and Women's Hospital, and Children's Hospital in Boston has been established in order to provide the necessary bioinformatics/clinical expertise and related clinical databases for systematic evaluation of heart rate variability in OSAS using state-of-the-art analytical techniques. The results will define the nonlinear dynamics of heart rate variability in OSAS as a basis for future development of a reliable and noninvasive ambulatory screening test for OSAS in children and adults.