Three-Dimensional Tissue-Like Sensing Arrays for Cerebral Brain Organoids

用于脑类器官的三维组织样传感阵列

• 批准号: 2394429
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2394429
• 关键词: Three; Dimensional; Tissue; Like; Sensing

Cerebral organoids sit at the interface between in vivo and in vitro, with complex cell composition, maturation and tissue architecture mimicking early brain development. This interdisciplinary project aims to facilitate the study of cerebral organoids through the development of a novel three-dimensional electrode sensing array. The array will monitor cellular activity through electrophysiological recording, providing insight into the neural network connections guiding organoid development. Further iterations of the original design will look to host chemical stimulation protocols to specifically control cellular functions. It is anticipated that the technologies developed in this project will find applications in other three-dimensional organoids and in vivo animal models. Research Areas: Microelectronic device technology, Sensors and instrumentation, Clinical technologies (excluding imaging)

大脑类器官位于体内和体外之间的界面，具有复杂的细胞组成，成熟和组织结构，模拟早期大脑发育。该跨学科项目旨在通过开发新型三维电极传感阵列来促进脑类器官的研究。该阵列将通过电生理记录监测细胞活动，从而深入了解指导类器官发育的神经网络连接。原始设计的进一步迭代将寻求宿主化学刺激方案来专门控制细胞功能。预计该项目开发的技术将在其他三维类器官和体内动物模型中得到应用。研究领域：微电子器件技术，传感器和仪器，临床技术（不包括成像）