Three-Dimensional Tissue-Like Sensing Arrays for Cerebral Brain Organoids

脑类器官位于体内和体外的界面，具有复杂的细胞组成、成熟和组织结构，模仿早期大脑发育。该跨学科项目旨在通过开发一种新型三维电极传感阵列来促进脑类器官的研究。该阵列将通过电生理记录来监测细胞活动，从而深入了解指导类器官发育的神经网络连接。原始设计的进一步迭代将着眼于宿主化学刺激方案，以特异性控制细胞功能。预计本项目开发的技术将在其他三维类器官和体内动物模型中得到应用。研究方向：微电子器件技术、传感器与仪器、临床技术（不含影像）

Cerebral organoids sit at the interface between in vivo and in vitro, with complex cell composition, maturation and tissue architecture mimicking early brain development. This interdisciplinary project aims to facilitate the study of cerebral organoids through the development of a novel three-dimensional electrode sensing array. The array will monitor cellular activity through electrophysiological recording, providing insight into the neural network connections guiding organoid development. Further iterations of the original design will look to host chemical stimulation protocols to specifically control cellular functions. It is anticipated that the technologies developed in this project will find applications in other three-dimensional organoids and in vivo animal models. Research Areas: Microelectronic device technology, Sensors and instrumentation, Clinical technologies (excluding imaging)