Investigations of Asbestos-Related Diseases

石棉相关疾病的调查

• 批准号: 6744137
• 负责人: Elizabeth A Putnam
• 金额: $ 20.63万
• 依托单位: UNIVERSITY OF MONTANA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-27 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6744137
• 关键词: asbestos; blood chemistry; clinical research; disease /disorder etiology; disease /disorder proneness /risk; environment related neoplasm /cancer; environmental contamination; environmental exposure; environmental health; experimental designs; gel electrophoresis; gene expression; genetic polymorphism; genetic susceptibility; human subject; meeting /conference /symposium; molecular genetics; nucleic acid sequence; nucleotides; pathologic process; phenotype; polymerase chain reaction; pulmonary fibrosis /granuloma; respiratory disorder epidemiology

DESCRIPTION (provided by applicant): The relationship between genetic susceptibility and environmental exposure in the development of disease has been hypothesized for many years. It has also been hypothesized that inherited differences in DNA sequence contribute to phenotypic variation, influencing an individual's risk of disease and response to the environment. The investigators propose to design novel techniques to investigate the role of single nucleotide polymorphisms (SNPs) in the association of asbestos exposure and the development of asbestos-related diseases. The hypothesis is that by bringing together an interdisciplinary team and outside experts, new epidemiological techniques can be created to more efficiently and reliably develop a novel study design. The mechanism to achieve this goal is to create opportunities for multidisciplinary interaction, as well as interaction with the study community. The scientific hypothesis is that SNPs in the genes involved in the asbestos-response pathway may be responsible for conferring sensitive or resistant phenotypes to asbestos-induced disease development in humans. To test the hypotheses, and to achieve the goals of the proposal, the investigators will: (1) educate the team members in each other's disciplines, (2) develop new molecular epidemiology techniques to investigate the connection between environmental exposure and susceptibility to exposure-induced diseases, (3) develop mechanisms for communication between study populations and investigators, (4) use pilot projects to develop preliminary data, and (5) prepare and submit a RO1 grant proposal using the novel methods developed by the team as validated by the preliminary data obtained from the pilot projects. Through these mechanisms, the investigators will establish the tools that will enable them to perform innovative investigations of the individual risks of disease development after asbestos exposure. The goal of this proposal is to prepare a RO1 application to address this question, having in place a strong team that has developed the best investigative methods possible. In the process, they will determine the polymorphisms important for susceptibility and/or resistance in genes involved in the asbestos-response pathway, for the ultimate purpose of improving the understanding of the mechanisms of these lung diseases.

描述（由申请人提供）： 遗传易感性与环境暴露的关系 疾病的发展已经假设了很多年。 它还 有人假设，DNA序列的遗传差异有助于 表型变异，影响个体的疾病风险和反应 对环境 研究人员建议设计新的技术， 研究单核苷酸多态性（SNPs）在 石棉暴露与石棉相关疾病发展的关系 疾病 假设是，通过汇集跨学科的知识 团队和外部专家，可以创建新的流行病学技术， 更有效、更可靠地开发新的研究设计。 的机制 实现这一目标是为多学科创造机会 互动，以及与学习社区的互动。 科学 一种假设是，石棉反应途径中基因的SNP 可能负责赋予敏感或耐药表型， 石棉引起的人类疾病发展。 为了验证假设，并实现提案的目标， 调查人员将：（1）教育团队成员了解彼此的学科， (2)发展新的分子流行病学技术， 环境暴露与对以下疾病易感性之间的联系 （3）发展沟通机制， 研究人群和研究者，（4）使用试点项目， 初步数据，以及（5）准备并提交一份RO 1赠款提案， 该团队开发的新方法已被初步数据验证， 从试点项目中获得的。 通过这些机制，调查人员将建立工具， 使他们能够对个人风险进行创新性的调查， 石棉暴露后的疾病发展。 本提案的目的是 准备一个RO 1应用程序来解决这个问题， 这是一个已经开发出最好的调查方法的团队。 在 过程中，他们将确定多态性的重要易感性 和/或抗性基因参与石棉反应途径， 提高对这些机制的理解的最终目的 肺部疾病