Patterns of Fatigue in Adolescents with Cancer

描述（由申请人提供）：本研究的广泛目标是调查在住院或门诊接受化疗的青少年癌症患者人群的疲劳。本研究的主要目的是描述一个周期（4周）化疗过程中的疲劳、严重程度、痛苦和功能干扰的模式。次要目标是：1）从青少年的角度描述疲劳随时间的影响; 2）探索可能影响该人群疲劳的变量，如年龄，诊断，治疗，血红蛋白水平和睡眠，以告知未来的研究; 3）确定在该人群中收集模式数据的可行性。将采用描述性研究设计，使用混合方法进行重复测量。本研究将入组25名13 - 19岁青少年的便利样本。将通过病历审查、每日疲劳评级、使用PedsQL多维疲劳量表的每周自我报告问卷和每周日志记录收集数据。将使用描述性、图形和非参数汇总统计分析定量数据。将分析定性数据的意义和主题，以开发疲劳体验的叙述性描述。

DESCRIPTION (provided by applicant): The broad goal of this research study is to investigate fatigue in a population of adolescents with cancer who are receiving chemotherapy in inpatient or outpatient settings. The primary aim of the study is to describe the patterns of fatigue, severity, distress, and interference with function during the course of one cycle (4 weeks) of chemotherapy. Secondary aims are to: 1) describe the impact of fatigue over time from the adolescent's perspective; 2) explore variables that may affect fatigue in this population, such as age, diagnosis, therapy, hemoglobin level, and sleep, in order to inform future research; and 3) determine the feasibility of collecting pattern data in this population. A descriptive research design with repeated measures using a mixed-methods approach will be used. A convenience sample of 25 adolescents, ages 13 to 19 years, will be enrolled in the study. Data will be collected through medical record review, daily ratings of fatigue, weekly self-report questionnaire using the PedsQL Multidimensional Fatigue Scale, and weekly diary entries. Quantitative data will be analyzed using descriptive, graphic, and non-parametric summary statistics. Qualitative data will be analyzed for meaning and themes to develop a narrative description of the fatigue experience.