Patterns of Fatigue in Adolescents with Cancer

描述(由申请人提供)：这项研究的广泛目标是调查住院或门诊接受化疗的青少年癌症患者群体中的疲劳情况。这项研究的主要目的是描述一个周期(4周)化疗期间的疲劳、严重程度、痛苦和功能障碍的模式。第二个目标是：1)从青少年的角度描述疲劳随时间的影响；2)探索可能影响这一人群中疲劳的变量，如年龄、诊断、治疗、血红蛋白水平和睡眠，以便为未来的研究提供信息；3)确定在这一人群中收集模式数据的可行性。将采用描述性研究设计，采用混合方法重复测量。这项研究将对25名年龄在13岁至19岁之间的青少年进行便利抽样。数据将通过病历回顾、每日疲劳评级、使用PedsQL多维疲劳量表的每周自我报告问卷和每周日记条目来收集。将使用描述性、图表和非参数汇总统计来分析量化数据。将分析定性数据的含义和主题，以开发对疲劳经历的叙述性描述。

DESCRIPTION (provided by applicant): The broad goal of this research study is to investigate fatigue in a population of adolescents with cancer who are receiving chemotherapy in inpatient or outpatient settings. The primary aim of the study is to describe the patterns of fatigue, severity, distress, and interference with function during the course of one cycle (4 weeks) of chemotherapy. Secondary aims are to: 1) describe the impact of fatigue over time from the adolescent's perspective; 2) explore variables that may affect fatigue in this population, such as age, diagnosis, therapy, hemoglobin level, and sleep, in order to inform future research; and 3) determine the feasibility of collecting pattern data in this population. A descriptive research design with repeated measures using a mixed-methods approach will be used. A convenience sample of 25 adolescents, ages 13 to 19 years, will be enrolled in the study. Data will be collected through medical record review, daily ratings of fatigue, weekly self-report questionnaire using the PedsQL Multidimensional Fatigue Scale, and weekly diary entries. Quantitative data will be analyzed using descriptive, graphic, and non-parametric summary statistics. Qualitative data will be analyzed for meaning and themes to develop a narrative description of the fatigue experience.