Simultaneous fMRI/ERP of Auditory Change Detection

描述(由申请人提供)：在两个实验中，将使用同步的ERP/fMRI来研究由无人注意的听觉变化(偏差)引起的非自愿注意转换的神经基质的时空特征，以及这一过程与自动(被动)和主动变化检测的关系。在第一个实验中，在选择性注意范式中，主要任务的难度会有所不同，以调节注意力切换到与任务无关的罕见听觉变化的速度。在每种情况下，比较ERP和对罕见听觉异常的大胆反应，有望揭示参与非自愿注意转换和变化检测的神经生成器的时间和空间特征。在第二个实验中，将使用分散注意力的范式来比较ERP和对听觉变化的大胆反应，这些反应会和不会引发随后对异常听觉事件的主动检测。这一比较有望提供有关非自愿注意转换和主动异常检测之间的关系的信息。听觉变化的自动检测被认为主要涉及颞叶皮质的听觉区域，而注意的非自愿转换和异常事件的显性检测分别被认为主要涉及背侧和腹侧前额叶皮质的结构。

DESCRIPTION (provided by applicant): The spatiotemporal characteristics of neural substrates of involuntary attention switching elicited by an unattended auditory change (deviant), and the relationship of this process to automatic (passive) and active change detection, will be investigated in two experiments using simultaneous ERP/fMRI. In a first experiment, the difficulty of a primary task in a selective attention paradigm will be varied in order to modulate the rate of attention switching to task-irrelevant rare auditory change. A comparison of the ERP and the BOLD responses to rare auditory deviants in each condition is expected to reveal the temporal and spatial characteristic of neural generators involved in involuntary attention-switching and change detection. In a second experiment, a divided attention paradigm will be used to compare ERP and BOLD responses to auditory change that do and do not elicit subsequent active detection of the deviant auditory event. This comparison is expected to yield information about the relation between involuntary attention switching and active deviant detection. The automatic detection of auditory change is hypothesized to involve predominantly auditory regions of the temporal cortex, whereas involuntary switching of attention and overt detection of the deviant event are thought to engage mainly structures in the dorsal and ventral prefrontal cortices, respectively.