Simultaneous fMRI/ERP of Auditory Change Detection

听觉变化检测的同步 fMRI/ERP

• 批准号: 6933174
• 负责人: MERAV SABRI
• 金额: $ 4.99万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6933174
• 关键词: attention; auditory discrimination; auditory stimulus; behavioral /social science research tag; brain mapping; clinical research; evoked potentials; functional magnetic resonance imaging; human subject; postdoctoral investigator; sound frequency; sound perception; young adult human (21-34)

DESCRIPTION (provided by applicant): The spatiotemporal characteristics of neural substrates of involuntary attention switching elicited by an unattended auditory change (deviant), and the relationship of this process to automatic (passive) and active change detection, will be investigated in two experiments using simultaneous ERP/fMRI. In a first experiment, the difficulty of a primary task in a selective attention paradigm will be varied in order to modulate the rate of attention switching to task-irrelevant rare auditory change. A comparison of the ERP and the BOLD responses to rare auditory deviants in each condition is expected to reveal the temporal and spatial characteristic of neural generators involved in involuntary attention-switching and change detection. In a second experiment, a divided attention paradigm will be used to compare ERP and BOLD responses to auditory change that do and do not elicit subsequent active detection of the deviant auditory event. This comparison is expected to yield information about the relation between involuntary attention switching and active deviant detection. The automatic detection of auditory change is hypothesized to involve predominantly auditory regions of the temporal cortex, whereas involuntary switching of attention and overt detection of the deviant event are thought to engage mainly structures in the dorsal and ventral prefrontal cortices, respectively.

描述（由申请人提供）：在两个实验中，我们将使用ERP/fMRI同时研究由无注意听觉变化（偏差）引起的非自愿注意转换的神经基质的时空特征，以及这一过程与自动（被动）和主动变化检测的关系。在第一个实验中，选择性注意范式中主要任务的难度将会改变，以调节注意力转向与任务无关的罕见听觉变化的速度。通过比较两种情况下的ERP和BOLD对罕见听觉偏差的反应，可以揭示参与非自愿注意转换和变化检测的神经发生器的时空特征。在第二个实验中，将使用分散注意范式来比较ERP和BOLD对听觉变化的反应，这些反应是否会引起对异常听觉事件的后续主动检测。这种比较有望产生关于非自愿注意转换和主动偏差检测之间关系的信息。听觉变化的自动检测被假设主要涉及颞叶皮层的听觉区域，而注意力的非自愿转换和异常事件的明显检测被认为主要涉及前额叶皮层的背侧和腹侧结构。