Simultaneous fMRI/ERP of Auditory Change Detection

描述（由申请人提供）：将在两个实验中使用同步ERP/fMRI研究由无人值守的听觉变化（异常）引起的非自愿注意转换的神经基质的时空特征，以及该过程与自动（被动）和主动变化检测的关系。在第一个实验中，选择性注意范式中的主要任务的难度将被改变，以调节注意切换到任务无关的罕见听觉变化的速率。比较ERP和BOLD反应罕见的听觉偏差在每种条件下，预计将揭示参与不自主注意转换和变化检测的神经发生器的时间和空间特性。在第二个实验中，一个分散注意力的范式将被用来比较ERP和BOLD响应听觉变化，不引起随后的主动检测的异常听觉事件。这种比较预计会产生信息之间的关系，无意识的注意转换和主动偏差检测。听觉变化的自动检测被假设主要涉及颞叶皮层的听觉区域，而注意力的不自主切换和异常事件的公开检测被认为主要分别涉及背侧和腹侧前额叶皮层的结构。

DESCRIPTION (provided by applicant): The spatiotemporal characteristics of neural substrates of involuntary attention switching elicited by an unattended auditory change (deviant), and the relationship of this process to automatic (passive) and active change detection, will be investigated in two experiments using simultaneous ERP/fMRI. In a first experiment, the difficulty of a primary task in a selective attention paradigm will be varied in order to modulate the rate of attention switching to task-irrelevant rare auditory change. A comparison of the ERP and the BOLD responses to rare auditory deviants in each condition is expected to reveal the temporal and spatial characteristic of neural generators involved in involuntary attention-switching and change detection. In a second experiment, a divided attention paradigm will be used to compare ERP and BOLD responses to auditory change that do and do not elicit subsequent active detection of the deviant auditory event. This comparison is expected to yield information about the relation between involuntary attention switching and active deviant detection. The automatic detection of auditory change is hypothesized to involve predominantly auditory regions of the temporal cortex, whereas involuntary switching of attention and overt detection of the deviant event are thought to engage mainly structures in the dorsal and ventral prefrontal cortices, respectively.