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Corticogeniculate Feedback in the Visual System

视觉系统中的皮质反馈

基本信息

批准号：
6790845
负责人：
Farran Briggs
金额：
$ 4.3万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-04-01 至 2007-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6790845
关键词：
Macaca mulatta action potentials brain electrical activity brain mapping electronic recording system electrostimulus experimental brain lesion lateral geniculate body neural conduction neural transmission neuronal guidance neurophysiology postdoctoral investigator single cell analysis visual cortex visual feedback visual pathways

项目摘要

DESCRIPTION (provided by applicant): An understanding of neuronal circuitry within the brain has important implications for diseases of circuits such as Alzheimer's and Parkinson's diseases. The visual system is an ideal model in which to study neural circuitry because it is precisely organized and much is known about its cellular and compartmental components. This proposal examines the function and anatomy of an important, yet elusive, pathway within the visual system: the corticogeniculate feedback pathway. Geniculate-projecting neurons in primary visual cortex which constitute the corticogeniculate pathway in the visual system will be studied using a three-tiered experimental approach. The first experiment involves recording from individual geniculate-projecting neurons within primary visual cortex in the conscious animal in order to elucidate their function in vivo. In the second experiment, individual geniculate-projecting neurons are identified by their physiology and labeled such that their sub-laminar location can be determined. The third experiment involves identifying the locations and morphological identities of geniculate-projecting neurons targeting specific regions of the lateral geniculate nucleus.

描述（由申请人提供）：对脑内神经元回路的理解对于诸如阿尔茨海默病和帕金森病的回路疾病具有重要意义。视觉系统是研究神经回路的理想模型，因为它是精确组织的，并且对其细胞和房室成分了解很多。这个建议检查的功能和解剖的一个重要的，但难以捉摸的，在视觉系统内的途径：皮质膝状体反馈通路。初级视皮层中的膝状体投射神经元构成视觉系统中的皮质膝状体通路，将使用三层实验方法进行研究。第一个实验是记录清醒动物初级视皮层内单个膝状体投射神经元，以阐明它们在体内的功能。在第二个实验中，单个膝状体投射神经元通过它们的生理学来识别并标记，使得可以确定它们的亚层位置。第三个实验涉及到确定的位置和形态学特性的膝状体投射神经元的特定区域的外侧膝状体核。