Central neural circuits involved in the febrile response

描述（由申请人提供）：本提案的目的是深入了解棕色脂肪组织（BAT）交感神经控制调节的核心机制。交感神经向BAT的流出在体温调节中起关键作用，并对能量消耗的调节有重要贡献。交感神经输出对BAT的调节受损或改变与潜在的危及生命的病理状况和疾病状态（如高热和肥胖）有关。本建议的具体目的是确定在发热反应期间参与交感神经向BAT流出调节的特定中枢神经系统通路。在实验诱导发烧期间，将抑制与交感神经向BAT流出调节有关的区域，以评估它们参与发热反应。此外，在不同的生理和药理学操作过程中，单个神经元在发热反应所必需区域内的活动将被记录下来，以便更好地了解与发热产热有关的回路。从这些实验中获得的见解可能最终导致治疗由BAT失调引起的病理状况的新方法。

DESCRIPTION (provided by applicant): The objective of this proposal is to gain insight into the central mechanisms underlying the regulation of sympathetic control of brown adipose tissue (BAT). Sympathetic outflow to BAT plays a critical role in thermoregulation and contributes significantly to the regulation of energy expenditure. Impairments or alterations in the regulation of sympathetic output to BAT are associated with potentially life threatening pathological conditions and disease states such as hyperthermia and obesity. The specific aims of this proposal are to determine the specific central nervous system pathways involved in the regulation of sympathetic outflow to BAT during the febrile response. Inhibition of areas implicated in the regulation of sympathetic outflow to BAT will be performed during experimentally induced fever in order to assess their involvement in the febrile response. In addition, the activity of single neurons within areas found to be necessary for the febrile response will be recorded during various physiological and pharmacological manipulations in order to gain a greater understanding of the circuits involved in febrile thermogenesis. Insights gained from these experiments may eventually lead to novel approaches for treating the pathological conditions resulting from disregulation of BAT.