Central neural circuits involved in the febrile response

参与发热反应的中枢神经回路

• 批准号: 7015059
• 负责人: CHRISTOPHER J MADDEN
• 金额: $ 5.2万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7015059
• 关键词: body temperature regulation; brain electronic stimulator; brown fat; central neural pathway /tract; hyperthermia; hypothalamus; immunocytochemistry; in situ hybridization; laboratory rat; male; microelectrodes; microinjections; neural information processing; neurons; postdoctoral investigator; preoptic areas; sympathetic nervous system; thermogenesis

DESCRIPTION (provided by applicant): The objective of this proposal is to gain insight into the central mechanisms underlying the regulation of sympathetic control of brown adipose tissue (BAT). Sympathetic outflow to BAT plays a critical role in thermoregulation and contributes significantly to the regulation of energy expenditure. Impairments or alterations in the regulation of sympathetic output to BAT are associated with potentially life threatening pathological conditions and disease states such as hyperthermia and obesity. The specific aims of this proposal are to determine the specific central nervous system pathways involved in the regulation of sympathetic outflow to BAT during the febrile response. Inhibition of areas implicated in the regulation of sympathetic outflow to BAT will be performed during experimentally induced fever in order to assess their involvement in the febrile response. In addition, the activity of single neurons within areas found to be necessary for the febrile response will be recorded during various physiological and pharmacological manipulations in order to gain a greater understanding of the circuits involved in febrile thermogenesis. Insights gained from these experiments may eventually lead to novel approaches for treating the pathological conditions resulting from disregulation of BAT.

描述（由申请人提供）：本提案的目的是深入了解棕色脂肪组织（BAT）交感神经控制调节的核心机制。 BAT 的交感神经流出在体温调节中发挥着关键作用，并对能量消耗的调节做出了重大贡献。 BAT 交感神经输出调节的损伤或改变与潜在危及生命的病理状况和疾病状态有关，例如高热和肥胖。该提案的具体目的是确定发热反应期间参与调节 BAT 交感神经流出的特定中枢神经系统通路。在实验诱导的发热过程中，将对涉及 BAT 交感神经流出调节的区域进行抑制，以评估它们对发热反应的参与。此外，在各种生理和药理学操作过程中，将记录发热反应所必需的区域内单个神经元的活动，以便更好地了解涉及发热产热的回路。从这些实验中获得的见解最终可能会带来治疗因 BAT 失调而导致的病理状况的新方法。