Sensitization & Cross-Sensitization to Psychostimulants

敏化

• 批准号: 6753573
• 负责人: PAMELA B YANG
• 金额: $ 2.68万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6753573
• 关键词: amphetamines; attention deficit disorder; behavior test; behavioral /social science research tag; behavioral habituation /sensitization; central nervous system stimulants; chordate locomotion; disease /disorder model; dosage; evoked potentials; female; gene environment interaction; genetic strain; juvenile animal; laboratory rat; mature animal; mental disorder chemotherapy; methylphenidate; neuropharmacology; predoctoral investigator

DESCRIPTION: (Provided by Applicant): Repeated treatment with methylphenidate (MPD; Ritalin) and other psychomotor stimulants, such as amphetamine and cocaine, has been shown to cause behavioral sensitization in rats and humans. Behavioral sensitization is characterized by an increase in locomotor and/or stereotypic behavior. It is not known, however, whether the behavioral sensitization produced by MPD involves the same neuronal mechanisms as amphetamine and cocaine. More importantly, chronic administration of MPD may also result in cross-sensitization with other psychostimulants. Methylphenidate is widely used to treat attention deficit/hyperactivity disorder (ADHD). The objectives of this study are to determine whether early exposure to MPD in juvenile rats increases their sensitivity to the drug when they are adult rats and whether treatment with MPD in juvenile and adult rats produces cross-sensitization to amphetamine. The study will consist of (1) monitoring the locomotor activity of two strains of rats (a model of ADHD and its control) before and after acute and repeated MPD administration when the rats are young and as adults followed by an amphetamine treatment and (2) evaluating sensory evoked potentials before and after drug treatment in freely moving rats with electrodes implanted in brain regions believed to be involved with ADHD, behavioral sensitization, and cross-sensitization.

描述：（申请人提供）： 用哌醋甲酯（MPD; Ritalin）和其他精神运动的重复治疗 刺激剂，例如苯丙胺和可卡因，已被证明会引起行为 大鼠和人类的敏化。行为敏化的特征是 运动和/或刻板印象行为的增加。但是，这尚不知道 MPD产生的行为敏化是否涉及相同的神经元 机理作为苯丙胺和可卡因。更重要的是，长期管理 MPD的of也可能导致其他精神刺激剂交叉敏感。 哌醋甲酯被广泛用于治疗注意力缺陷/多动症 疾病（多动症）。这项研究的目的是确定早期是否 当少年大鼠接触MPD时，会增加对药物的敏感性 他们是成年大鼠，是否在少年和成年大鼠中用MPD治疗 对苯丙胺产生交叉敏化。该研究将包括（1） 监测两种大鼠菌株的运动活性（ADHD模型和 它的控制）急性之前和之后，重复MPD给药 大鼠年轻，作为成年人，然后进行苯丙胺治疗，（2） 在自由的药物治疗之前和之后评估感觉的诱发潜力 将大鼠带有植入的电极，被认为涉及的大脑区域 使用多动症，行为敏化和交叉敏化。

项目成果

Methylphenidate and amphetamine modulate differently the NMDA and AMPA glutamatergic transmission of dopaminergic neurons in the ventral tegmental area.

• DOI: 10.1016/j.lfs.2004.10.076
• 发表时间: 2005-06
• 期刊: Life sciences
• 影响因子: 6.1
• 作者: B. Prieto-Gómez;A. Vázquez-Alvarez;J. L. Martínez-Peña;C. Reyes-vazquez;P. Yang;Nachum Dafny

Adolescent rat circadian activity is modulated by psychostimulants.

• DOI: 10.1016/j.brainres.2011.10.027
• 发表时间: 2012-01-11
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Bergheim M;Yang PB;Burau KD;Dafny N
• 通讯作者: Dafny N

Chronic methylphenidate modulates locomotor activity and sensory evoked responses in the VTA and NAc of freely behaving rats.

慢性哌醋甲酯调节自由行为大鼠的 VTA 和 NAc 的运动活动和感觉诱发反应。

• DOI: 10.1016/j.neuropharm.2006.04.014
• 发表时间: 2006
• 期刊: Neuropharmacology
• 影响因子: 4.7
• 作者: Yang,PamelaB;Swann,AlanC;Dafny,Nachum
• 通讯作者: Dafny,Nachum

Dopaminergic ventral tegmental neurons modulated by methylphenidate.

哌醋甲酯调节多巴胺能腹侧被盖神经元。

• DOI: 10.1016/j.lfs.2003.07.047
• 发表时间: 2004
• 期刊: Life sciences
• 影响因子: 6.1
• 作者: Prieto-Gomez,B;Benitez,MT;Vazquez-Alvarez,AM;Yang,PB;ReyesVazquez,C;Dafny,N
• 通讯作者: Dafny,N

Repetitive ritalin treatment modulates the diurnal activity pattern of young SD male rats.

重复利他林治疗可调节年轻 SD 雄性大鼠的昼夜活动模式。

• DOI: 10.2174/1871524911006030247
• 发表时间: 2010
• 期刊: Central nervous system agents in medicinal chemistry
• 作者: Algahim,MohameFodhl;Yang,PamelaBoi;Burau,KeithDean;Swann,AllanCraig;Dafny,Nachum
• 通讯作者: Dafny,Nachum