Role of 5-HT2A Receptors in MDMA induced Behavior

描述：(申请人提供)： 滥用取代苯丙胺3，4-亚甲基二氧基甲基苯丙胺(MDMA) 近年来迅速增加，特别是在青少年中。用户 报告称，MDMA可以提升情绪和信心，并增强与 其他。然而，MDMA也被证明会产生不受欢迎的变化 情绪、睡眠、记忆和体温调节。的确切作用机制 MDMA是未知的，但被认为部分是通过MDMA诱导的 通过逆转5-羟色胺转运体来释放5-羟色胺。因为5-羟色胺 释放在调节MDMA的影响方面很重要，我们的实验室一直专注于 确定特定的5-羟色胺受体在行为效应中的作用 摇头丸的名字。初步数据表明，5-HT2A受体的激活是 在产生由MDMA引起的超运动活动方面很重要，并且 文献表明5-羟色胺在高血压的发生中起作用 MDMA诱导条件性位置偏爱(CPP)。CPP和Momotor都是 活性是通过激活中隔伏核的多巴胺途径产生的。 因此，这项提案的目的是确定 高运动性运动中的5-HT2a受体及其条件性刺激效应 摇头丸。

DESCRIPTION: (Provided by Applicant): Abuse of the substituted amphetamine 3,4-Methylenedioxymethamphetamine (MDMA) has rapidly increased in recent years, particularly among adolescents. Users report that MDMA elevates mood and confidence and increases connectedness with others. However, MDMA has also been shown to produce undesirable alterations in mood, sleep, memory, and thermoregulation. The exact mechanisms of action for MDMA are unknown, but are thought to be mediated partly through MDMA-induced serotonin release via reversal of the serotonin transporter. Since serotonin release is important in mediating the effects of MDMA, our lab has focused on determining the role of specific serotonin receptors in the behavioral effects of MDMA. Preliminary data suggest that activation of the 5-HT2A receptor is important in generating hyperlocomotor activity elicited by MDMA, and the literature suggests that serotonin plays a role in the generation of MDMA-induced conditioned place preference (CPP). Both CPP and locomotor activity are generated by activation of the mesoaccumbens dopamine pathway. Therefore, the purpose of this proposal is to determine the involvement of 5-HT2A receptors in the hyperlocomotive and conditioned stimulus effects of MDMA.