Role of 5-HT2A Receptors in MDMA induced Behavior

5-HT2A 受体在 MDMA 诱导行为中的作用

• 批准号: 6719032
• 负责人: David Vance Herin
• 金额: $ 2.83万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6719032
• 关键词: 3,4 methylenedioxymethamphetamine; adolescence (12-20); behavior; behavior test; behavioral /social science research tag; conditioning; cues; dopamine; drug abuse; immunocytochemistry; ketanserin; laboratory rat; memory disorders; mood disorders; neuromuscular system; neuropharmacology; nucleus accumbens; predoctoral investigator; psychomotor function; receptor expression; serotonin receptor; serotonin transporter; sleep disorders

DESCRIPTION: (Provided by Applicant): Abuse of the substituted amphetamine 3,4-Methylenedioxymethamphetamine (MDMA) has rapidly increased in recent years, particularly among adolescents. Users report that MDMA elevates mood and confidence and increases connectedness with others. However, MDMA has also been shown to produce undesirable alterations in mood, sleep, memory, and thermoregulation. The exact mechanisms of action for MDMA are unknown, but are thought to be mediated partly through MDMA-induced serotonin release via reversal of the serotonin transporter. Since serotonin release is important in mediating the effects of MDMA, our lab has focused on determining the role of specific serotonin receptors in the behavioral effects of MDMA. Preliminary data suggest that activation of the 5-HT2A receptor is important in generating hyperlocomotor activity elicited by MDMA, and the literature suggests that serotonin plays a role in the generation of MDMA-induced conditioned place preference (CPP). Both CPP and locomotor activity are generated by activation of the mesoaccumbens dopamine pathway. Therefore, the purpose of this proposal is to determine the involvement of 5-HT2A receptors in the hyperlocomotive and conditioned stimulus effects of MDMA.

描述：（申请人提供）： 取代安非他明的滥用 近年来，特别是在青少年中，这种情况迅速增加。用户 报告说，MDMA提高情绪和信心，并增加与 他人然而，MDMA也被证明会产生不良的改变， 情绪、睡眠、记忆和体温调节。的确切作用机制 MDMA是未知的，但被认为是介导的部分通过MDMA诱导 通过逆转血清素转运体释放血清素。自从血清素 释放在介导MDMA的影响方面很重要，我们的实验室专注于 确定特定5-羟色胺受体在行为效应中的作用 MDMA。初步数据表明，5-HT 2A受体的激活是 重要的是产生由MDMA引起的过度运动活动， 文献表明，血清素在产生 MDMA诱导的条件性位置偏爱（CPP）。CPP和运动 活性是通过激活中脑多巴胺途径产生的。 因此，本提案的目的是确定 5-HT 2A受体在超运动和条件刺激效应中的作用 摇头丸