Role of 5-HT2A Receptors in MDMA induced Behavior

5-HT2A 受体在 MDMA 诱导行为中的作用

• 批准号: 6626252
• 负责人: David Vance Herin
• 金额: $ 2.75万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6626252
• 关键词: 3,4 methylenedioxymethamphetamine; adolescence (12-20); behavior; behavior test; behavioral /social science research tag; conditioning; cues; dopamine; drug abuse; immunocytochemistry; ketanserin; laboratory rat; memory disorders; mood disorders; neuromuscular system; neuropharmacology; nucleus accumbens; predoctoral investigator; psychomotor function; receptor expression; serotonin receptor; serotonin transporter; sleep disorders

DESCRIPTION: (Provided by Applicant): Abuse of the substituted amphetamine 3,4-Methylenedioxymethamphetamine (MDMA) has rapidly increased in recent years, particularly among adolescents. Users report that MDMA elevates mood and confidence and increases connectedness with others. However, MDMA has also been shown to produce undesirable alterations in mood, sleep, memory, and thermoregulation. The exact mechanisms of action for MDMA are unknown, but are thought to be mediated partly through MDMA-induced serotonin release via reversal of the serotonin transporter. Since serotonin release is important in mediating the effects of MDMA, our lab has focused on determining the role of specific serotonin receptors in the behavioral effects of MDMA. Preliminary data suggest that activation of the 5-HT2A receptor is important in generating hyperlocomotor activity elicited by MDMA, and the literature suggests that serotonin plays a role in the generation of MDMA-induced conditioned place preference (CPP). Both CPP and locomotor activity are generated by activation of the mesoaccumbens dopamine pathway. Therefore, the purpose of this proposal is to determine the involvement of 5-HT2A receptors in the hyperlocomotive and conditioned stimulus effects of MDMA.

描述：（由申请人提供）： 滥用取代苯丙胺 3,4-亚甲二氧基甲基苯丙胺 (MDMA) 近年来迅速增加，特别是在青少年中。用户 报告称 MDMA 可以提升情绪和信心，并增强与他人的联系 其他的。然而，MDMA 也被证明会产生不良的改变 情绪、睡眠、记忆力和体温调节。确切的作用机制 MDMA 未知，但被认为部分通过 MDMA 诱导介导 通过逆转血清素转运蛋白释放血清素。由于血清素 释放对于调节 MDMA 的影响非常重要，我们的实验室重点关注 确定特定血清素受体在行为效应中的作用 摇头丸。初步数据表明 5-HT2A 受体的激活是 对于 MDMA 引起的过度运动活动很重要，并且 文献表明，血清素在产生 MDMA 诱导的条件性位置偏好 (CPP)。 CPP 和运动 活性是通过激活中伏隔多巴胺途径产生的。 因此，本提案的目的是确定 5-HT2A 受体在超运动和条件刺激作用中的作用 摇头丸。