Biocomputing: Integrating Molecular/Organ-Level Function

描述(由申请人提供)：我们将开发必要的基础设施来执行生物医学系统的高级计算模拟，重点放在分子机制引发器官水平反应的多尺度问题上。中心的活动将在不同教育背景的教员和研究助理(理论家、计算和实验科学家、临床研究人员)之间建立跨学科的联系，并将在杜兰大学的教育和研究任务之间建立实质性的联系。为了使我们的前NPEBC发展成为NPEBC，我们将实现以下目标： 目标1：我们将启动一项研究计划，将生物医学系统中的分子反应与器官水平的反应联系起来。 目标2：我们将开发一个物理和智力基础设施，以支持和促进多学科教育工作者和研究人员团体，因为他们创造和教授生物医学计算技术，用于研究生物医学系统中的多尺度问题。 目标3：我们将开发教育和外展机会，培养下一代生物医学研究人员。 开发项目将侧重于对心脏、肺和骨骼的多尺度生物医学调查；然而，所开发的一般方法将适用于许多生理系统的研究。每个研究项目都将把在计算建模和模拟方面有专长的研究人员与生物医学系统的研究人员聚集在一起。这些项目启动了杜兰大学生物医学工程、数学和化学工程系教职员工之间的新合作，并将为新奥尔良泽维尔大学的学生和教职员工提供机会。

DESCRIPTION (provided by applicant): We will develop the essential infrastructure to perform advanced computational simulations of biomedical systems with a focus on multi-scale problems where molecular mechanisms induce organ-level responses. Center activities will develop interdisciplinary links between cohorts of faculty and research associates of diverse educational backgrounds (theoreticians, computational and experimental scientists, clinical investigators), and will create a substantial link between the educational and research missions of Tulane University. In order for our pre-NPEBC to develop into an NPEBC, we will attain the following objectives: Objective 1: We will initiate a research program that will link molecular to organ-level responses in biomedical systems. Objective 2: We will develop a physical and intellectual infrastructure that will support and promote multidisciplinary groups of educators and researchers as they create and teach biomedical computing techniques for the investigation of multiple-scale problems in biomedical systems. Objective 3: We will develop educational and outreach opportunities to train the next generation of biomedical researchers. Development projects will focus on multi-scale biomedical investigations of the heart, lung and bone; however, the general approaches developed will be applicable to the study of many physiological systems. Each research project will bring together investigators with expertise in computational modeling and simulation with researchers of biomedical systems. These projects initiate new collaborations between faculty members in the Departments of Biomedical Engineering, Mathematics and Chemical Engineering at Tulane University and will provide opportunities for students and faculty at Xavier University of New Orleans.