Cancer Center Planning Grant (P20)

这份申请代表了一项计划拨款的提案，该基金将在俄克拉荷马大学健康科学中心(OUHSC)建立一个由NCI指定的癌症中心。拟议的方案要么是特定于器官部位的，要么就基础科学和预防/控制科学而言，具有很强的翻译性。每个项目的共同目标是减少癌症的发病率，促进癌症的早期诊断，通过改善多模式的临床护理和跨学科的基础科学来提高生存率，并促进与服务不足的社区的联系。妇科和乳房计划的成员拥有丰富的临床专业知识、积极的赠款资助以及各种基础、临床和转化性研究兴趣。在这两个项目中，基础科学家和临床研究人员的整合都是有意的。该模型在整个中心的扩展吸收了基础科学专业知识和《细胞周期控制与癌症发生》中所描述的那种假说生成研究。社区癌症预防和控制研究的目标是外展、以社区为重点的医学和科学，以及针对俄克拉荷马州其他服务不足的社区的倡议。在这些领域，已经存在大量的基础科学方面的临床专业知识和研究人员。发展基金和种子基金将用于鼓励方案增长和刺激新方案的开发。OUHSC将继续在过去五年中对该中心进行大量投资，包括2000万美元的招聘，在未来五年内建设一个25,000平方英尺的癌症门诊课程中心的主要目标将是增加NCI赞助的直接资金，从4.4美元。每年的直接成本为100万至800万美元。俄亥俄州立大学癌症中心的进一步发展将确保在美国这一地区进行独特的癌症研究，并为目前没有替代NCI指定癌症中心的大量人口提供最先进的癌症护理。

This application represents a proposal for a Planning Grant to develop an NCI-designated Cancer Center at the University of Oklahoma Health Sciences Center (OUHSC). The proposed programs are either organ-site specific or in the case of both basic and prevention/control sciences, highly translational in nature. The common goals of each program are to decrease the incidence and promote early diagnosis of cancer, to improve survival via improving multi-modality clinical care and interdisciplinary basic science, and to facilitate outreach to underserved communities. Members of the Gynecology and Breast Programs have significant clinical expertise, active grant funding and a diversity of basic, clinical and translational research interests. In both of these programs, the integration of the basic scientists and clinical investigators has been intentional. Expansion of this model throughout the Center has drawn in basic science expertise and the kind of hypothesis-generating research described in Cell Cycle Control and Carcinogenesis. Community Cancer Prevention and Control Research targets outreach, community focused medicine and science, and initiatives designed to other underserved communities in Oklahoma. Significant clinical expertise and investigators in basic science in these areas already exist. Developmental and seed funds will be utilized to encourage programmatic growth and stimulate new program development. OUHSC will continue the significant investment that it has undertaken in the Center in the past five years including $20 million for recruitment, construction of a 25,000 square foot outpatient cancer course of the next five years a major goal of the Center will be to increase direct NCI sponsored funding from $4.4. million dollars to $8 million dollars in annual direct costs. Further growth of the OU Cancer Center will ensure unique cancer research to this region of the United States and accessibility for state of the art cancer care for a large population that currently has no alternative NCI-designated cancer center.