NCCU EXPORT Center for Excellence

描述(由申请者提供)：申请资金在北卡罗来纳中央大学建立一个出口卓越中心，通过与北卡罗来纳大学教堂山分校、杜克大学医学中心和维克森林大学医学院的伙伴关系，重点关注少数族裔的健康差距。拟议研究项目的一个共同主题是，非裔美国人社区的健康差异是复杂的基因-环境相互作用的结果，心理社会和环境压力影响具有易感基因的个人，并导致心血管疾病、药物滥用和复发以及癌症的发生率和严重性增加。这些项目将结合使用人类种群研究和动物模型，分成三个独立的研究核心部分。这项研究将得到三个独立的共享资源核心的支持：生物信息学、基因组学和动物资源与转基因基因分型。国家协调中心出口中心的总体规划和日常职能将由一个行政核心领导，该核心又将与一个社区外联核心和一个教育和培训核心密切相关。社区外展中心将肩负起多管齐下的使命，即制定基于NCCU的社区健康和疾病风险教育方案，并协调NCCU的学生和工作人员在开展合作研究活动中的使用。教育和培训核心将监督从高中到学士学位的少数民族学生的实验室和课堂培训，以及NCCU在生物医学科学领域的博士项目的发展。预计提出的计划将导致形成一个以HBU为中心的示范出口中心，通过积极的分子遗传学研究以及通过创建和实施研究、培训和社区外联活动来解决重要的少数群体健康问题。

DESCRIPTION (provided by applicant): Funds are requested to develop an EXPORT Center of Excellence at North Carolina Central University that focuses on minority health disparities through partnerships with the University of North Carolina at Chapel Hill, Duke University Medical Center and Wake Forest University School of Medicine. A common theme of the proposed research projects is that health disparities in the African American community are the result of complex gene-environment interactions such that psychosocial and environmental stresses impact individuals with a susceptible genotype and lead to a increased incidence and severity of cardiovascular disease, substance abuse and recidivism, and cancer. These projects will be addressed in three separate research core components using a combination of human population studies and animal models. The research will be supported by three separate Shared Resource Cores: Bioinformatics, Genomics, and Animal Resources & Transgenic Genotyping. The overall planning and day to day function of the NCCU EXPORT Center will be directed by an Administrative core which will in turn be closely associated with a Community Outreach Core and an Education and Training Core. The Community Outreach core will have the multipronged mission of developing NCCU-based programs for community health and disease risk education and for coordinating the use of NCCU student and staff in the conduct of cooperative research activities. The Education and Training Core will oversee laboratory and classroom training of minority students from high school through the Bachelor's degree and the development of a doctoral program at NCCU in the area of Biomedical Sciences. It is anticipated that the plan that is presented will result in the formation of a model HBU-centered EXPORT center that addresses important minority health issues through active molecular genetics research and through the creation and implementation of research, training and community outreach activities