CART Peptide Regulation of Neuroendocrine Function
CART肽调节神经内分泌功能
基本信息
- 批准号:6837043
- 负责人:
- 金额:$ 4.73万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-09-01 至 2006-08-31
- 项目状态:已结题
- 来源:
- 关键词:adrenocorticotropic hormoneautoradiographybinding sitescentral nervous system stimulantscorticotropin releasing factorhigh performance liquid chromatographyhypothalamic pituitary adrenal axishypothalamusin situ hybridizationlaboratory ratmessenger RNAneuroendocrine systemneurohormonesneuropeptidesneuroregulationpituitary glandpostdoctoral investigatorradioimmunoassayvasopressins
项目摘要
DESCRIPTION (provided by applicant):
CART was first identified as a mRNA transcript that was upregulated in the rat striatum in response to administration of psychostimulant drugs. CART peptides are widely distributed throughout the central nervous system (CNS) and derive from one of the most abundantly expressed hypothalamic transcripts. Several studies have provided evidence that CART may play a role in the regulation of the HPA axis. However, it is not clear whether CART mediates HPA axis function at the level of the pituitary or if CART regulates activation of the HPA axis through interaction with classic hypothalamic releasing factors. Therefore, characterization of the effects of both central and peripheral administration of CART on the regulation of adrenocorticotropic hormone (ACTH) release will provide key information about the underlying mechanisms of CART's effects on the HPA axis. A second area of interest centers on the putative effects of CART administration on the expression and release of corticotropin-releasing factor (CRF) and vasopressin (AVP) in the hypothalamus. To date there has been little information generated on the subject of a putative CART receptor; therefore, a final aim of this proposal is to isolate and clone a putative receptor for CART. Identification of such a protein will greatly enhance our understanding of the physiological role of CART. The overall goal of our proposed research is to determine the underlying mechanisms of CART regulation of the HPA axis to understand the physiological significance of CART peptides in neuroendocrine centers of the CNS.
描述(由申请人提供):
CART首先被鉴定为在大鼠纹状体中响应于给予精神兴奋剂药物而上调的mRNA转录物。CART肽广泛分布于整个中枢神经系统(CNS)中,并且衍生自表达最丰富的下丘脑转录物之一。一些研究提供了证据表明,CART可能在HPA轴的调节中发挥作用。然而,目前尚不清楚CART是否在垂体水平介导HPA轴功能,或者CART是否通过与经典的下丘脑释放因子相互作用调节HPA轴的激活。因此,表征CART的中枢和外周给药对促肾上腺皮质激素(ACTH)释放调节的作用将提供关于CART对HPA轴作用的潜在机制的关键信息。第二个感兴趣的领域集中在CART给药对下丘脑中促肾上腺皮质激素释放因子(CRF)和加压素(AVP)的表达和释放的推定作用上。迄今为止,几乎没有关于推定的CART受体的信息;因此,本提案的最终目的是分离和克隆推定的CART受体。这种蛋白质的鉴定将大大提高我们对CART生理作用的理解。我们提出的研究的总体目标是确定CART调节HPA轴的潜在机制,以了解CART肽在CNS神经内分泌中心的生理意义。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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SEAN M SMITH其他文献
SEAN M SMITH的其他文献
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{{ truncateString('SEAN M SMITH', 18)}}的其他基金
CART Peptide Regulation of Neuroendocrine Function
CART肽调节神经内分泌功能
- 批准号:
6953599 - 财政年份:2004
- 资助金额:
$ 4.73万 - 项目类别:
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