Serotonergic Function in Dementia

痴呆症中的血清素能功能

• 批准号: 6816956
• 负责人: TIFFANY WingChoy CHOW
• 金额: $ 5.49万
• 依托单位: ROTMAN RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6816956
• 关键词: anxiety; behavioral /social science research tag; clinical depression; clinical research; dementia; deoxyglucose; frontal lobe /cortex; human old age (65+); human subject; magnetic resonance imaging; neuropharmacology; neurophysiology; neuropsychology; obsessive compulsive disorder; positron emission tomography; postdoctoral investigator; radiotracer; receptor binding; serotonin; serotonin receptor; temporal lobe /cortex

DESCRIPTION (provided by applicant): This study will initiate the candidate's career goal of finding evidence to guide management of neuropsychiatric disturbances in dementia by allowing her training in PET imaging with a serotonin receptor-specific radioligand and statistical analysis. The synergistic expertise of the mentors and facilities available to her at the University of Toronto cannot be reproduced in the US for this study. HYPOTHESIS: Anxiety, obsessive-compulsive behaviors and dysphoria in frontotemporal lobar degeneration (FTLD) are associated with a diminution in 5HT1A receptor density in frontal and temporal cortex. PET imaging can demonstrate and quantify these differences. SPECIFIC AIMS: 1) Quantify the difference in binding potential at 5HT1A receptors as derived from PET imaging with [11C]WAY-100635 in frontal and temporal cortical regions of interest between FTLD subjects and normal, age- and education-matched controls. 2) Compare the same PET findings between FTLD subjects with and without the mood symptoms. If changes in serotonergic function in frontal regions of interest correlate with the symptoms, this study will provide the basis for further investigations to identify serotonergic pharmacotherapy for such patients.

描述（由申请人提供）： 这项研究将启动候选人的职业目标，即通过允许她接受血清素受体特异性放射配体的 PET 成像培训和统计分析来寻找证据来指导痴呆症神经精神障碍的治疗。本研究无法在美国复制多伦多大学的导师和设施的协同专业知识。 假设：额颞叶变性 (FTLD) 中的焦虑、强迫行为和烦躁与额叶和颞叶皮层 5HT1A 受体密度减少有关。 PET 成像可以证明并量化这些差异。 具体目标： 1) 量化 FTLD 受试者与正常、年龄和教育程度匹配的对照组之间感兴趣的额叶和颞叶皮层区域中使用 [11C]WAY-100635 进行 PET 成像得出的 5HT1A 受体结合电位的差异。 2) 比较有和没有情绪症状的 FTLD 受试者之间相同的 PET 结果。 如果感兴趣的额叶区域的血清素能功能的变化与症状相关，那么本研究将为进一步研究提供基础，以确定此类患者的血清素能药物治疗。