Serotonergic Function in Dementia

痴呆症中的血清素能功能

• 批准号: 6916949
• 负责人: TIFFANY WingChoy CHOW
• 金额: $ 0.55万
• 依托单位: ROTMAN RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6916949
• 关键词: anxiety; behavioral /social science research tag; clinical depression; clinical research; dementia; deoxyglucose; frontal lobe /cortex; human old age (65+); human subject; magnetic resonance imaging; neuropharmacology; neurophysiology; neuropsychology; obsessive compulsive disorder; positron emission tomography; postdoctoral investigator; radiotracer; receptor binding; serotonin; serotonin receptor; temporal lobe /cortex

DESCRIPTION (provided by applicant): This study will initiate the candidate's career goal of finding evidence to guide management of neuropsychiatric disturbances in dementia by allowing her training in PET imaging with a serotonin receptor-specific radioligand and statistical analysis. The synergistic expertise of the mentors and facilities available to her at the University of Toronto cannot be reproduced in the US for this study. HYPOTHESIS: Anxiety, obsessive-compulsive behaviors and dysphoria in frontotemporal lobar degeneration (FTLD) are associated with a diminution in 5HT1A receptor density in frontal and temporal cortex. PET imaging can demonstrate and quantify these differences. SPECIFIC AIMS: 1) Quantify the difference in binding potential at 5HT1A receptors as derived from PET imaging with [11C]WAY-100635 in frontal and temporal cortical regions of interest between FTLD subjects and normal, age- and education-matched controls. 2) Compare the same PET findings between FTLD subjects with and without the mood symptoms. If changes in serotonergic function in frontal regions of interest correlate with the symptoms, this study will provide the basis for further investigations to identify serotonergic pharmacotherapy for such patients.

描述（由申请人提供）： 这项研究将启动候选人的职业目标，即通过允许她接受5-羟色胺受体特异性放射性配体PET成像和统计分析的培训，找到指导痴呆症神经精神障碍管理的证据。她在多伦多大学获得的导师和设施的协同专业知识无法在美国复制。 假设：额颞叶变性（FTLD）中的焦虑、强迫行为和烦躁不安与额叶和颞叶皮质中5 HT 1A受体密度的减少有关。PET成像可以显示和量化这些差异。 具体目标：1）量化FTLD受试者与正常、年龄和教育匹配的对照之间在感兴趣的额叶和颞叶皮质区域中由[11 C]WAY-100635的PET成像导出的5 HT 1A受体处的结合电位的差异。2)比较有和没有情绪症状的FTLD受试者之间相同的PET结果。 如果额叶感兴趣区域的多巴胺能功能变化与症状相关，则本研究将为进一步研究确定此类患者的多巴胺能药物治疗提供基础。