Characterization of Tendon Damage Accumulation

肌腱损伤累积的表征

• 批准号: 6760015
• 负责人: VINCENT M WANG
• 金额: $ 4.89万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6760015
• 关键词: bioengineering /biomedical engineering; biomechanics; collagen; confocal scanning microscopy; electron microscopy; histology; laboratory rat; light microscopy; mathematical model; mechanical stress; morphology; orthopedics; postdoctoral investigator; tendon injury; tendons; viscosity

DESCRIPTION (provided by applicant): Tendon injuries such as those of repetitive overuse and cumulative trauma (e.g., carpal tunnel syndrome) are a major source of pain and disability, yet the mechanism of low-level injury and progression of tendon pathology is unknown. Animal models of tendon healing, while important, do not provide insight into the response of tendons to cumulative wear and tear. A comprehensive series of experiments is proposed herein to systematically characterize damage initiation and progression resulting from controlled levels of imposed mechanical fatigue. A novel mechanical testing protocol will be developed and implemented to reproducibly induce increasing levels of tendon damage which will be quantified using engineering damage parameters. Additional indices of tendon viscoelastic behavior will be obtained from mathematical modeling of the experimental data. Microstructural studies on fatigue-loaded tendons will be used to define the physical manifestation of fatigue damage and to correlate the structural changes with mechanical measures of degradation. Successful completion of these proposed studies will establish the necessary damage-degradation relationships needed to assess in vivo cellular responses following tendon injury.

描述（由申请人提供）：肌腱损伤，如重复性过度使用和累积性创伤（例如，腕管综合征）是疼痛和残疾的主要来源，但低水平损伤和肌腱病理进展的机制尚不清楚。肌腱愈合的动物模型虽然很重要，但不能深入了解肌腱对累积磨损和撕裂的反应。本文提出了一个全面的系列实验，系统地表征损伤的起始和进展所造成的控制水平的机械疲劳。将开发并实施一种新的力学测试方案，以可重复地诱导肌腱损伤水平的增加，并使用工程损伤参数对其进行量化。通过对试验数据进行数学建模，可获得肌腱粘弹性行为的其他指标。疲劳加载钢筋束的微观结构研究将用于定义疲劳损伤的物理表现，并将结构变化与退化的机械措施相关联。成功完成这些拟议的研究将建立必要的损伤-降解关系，以评估肌腱损伤后的体内细胞反应。