MINORITY PREDOCTORAL FELLOWSHIP PROGRAM

少数族裔博士前奖学金计划

• 批准号: 6701274
• 负责人: Melissa Sanchez
• 金额: $ 2.99万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6701274
• 关键词: gene therapy; genetic techniques; molecular biology; transfection /expression vector; virus infection mechanism

My primary interest involves the study of animal genetic diseases as models for human genetic diseases. Gene transfer techniques aimed to replace defective genes with functional genes in diseased animals have become one of my major interests in this specific area. Vast understanding of the viral vectors utilized in these techniques is essential for effective gene therapy procedures. Therefore, understanding the basic biology of viruses and viral-host interactions is extremely important to improve their use as vehicles for gene therapy. My research interests within virology are broad including viral entry, genes that confer virulence, and tissue tropism. Learning about the molecular biology of viruses and the viral infection will aid in the development of safe and effective viral vectors to improve gene therapy techniques utilized as treatments for genetic diseases.

我的主要兴趣是研究动物遗传疾病作为人类遗传疾病的模型。 基因转移技术旨在用功能基因取代患病动物中的缺陷基因，已成为我在这一特定领域的主要兴趣之一。 对这些技术中使用的病毒载体的广泛理解对于有效的基因治疗程序是必不可少的。 因此，了解病毒的基本生物学和病毒-宿主相互作用对于改善其作为基因治疗载体的使用极其重要。 我在病毒学方面的研究兴趣广泛，包括病毒进入，赋予毒力的基因和组织嗜性。 了解病毒的分子生物学和病毒感染将有助于开发安全有效的病毒载体，以改善用于治疗遗传性疾病的基因治疗技术。