UNIVERSITY OF ARIZONA FOR INITIATIVE FOR MINORITY PHD'S

亚利桑那大学少数族裔博士倡议

• 批准号: 6699014
• 负责人: Maria Teresa Velez
• 金额: $ 32.52万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6699014
• 关键词: education evaluation /planning; health science research potential; health science research support; minority health professional; predoctoral investigator; science education; training; university student

This is a joint Harvard-Brandeis program project, with goals that include both methodological developments and cell-biological applications. The four major goals are: (1) advance methods for obtaining atomic models of large structure by docking and refining atomic models of the component parts in molecular maps from electron cryomicroscopy (cryoEM); (2) improve the accuracy and resolution of the molecular maps we can obtain from cryoEM of single particles, accelerate 2D crystal structure determination, through development of molecular replacement and phase extension methods; (4) improve use of molecular maps from cryoEM to initiate phase determination in studies of large assemblies. By x-ray crystallography. There are four major projects, three cores, and a set of associated projects. The major and associated projects focus on the following biological systems: (1) the actin cytoskeleton; (2) viruses and viral entry into cells; (3) membrane proteins, especially members of the MIP and MAPEG families; (4) antibiotic peptide synthetases; (5) spliceosome assemblies; (6) the phase T7 replication complex, ("replisome"). The cores, which are a central component of the collaborative effort, support shared state-of-the-art electron microscope facilities, software development, and administration of the consortium.

这是一个联合哈佛 - 布兰德计划项目，其目标包括方法论发展和细胞生物学应用。四个主要目标是：（1）通过对电子冷冻机镜（Cryoem）中的分子图中的分子图中的组分部分的原子模型（Cryoem）在分子图中获取大结构的原子模型的提前方法； （2）提高我们可以从单个颗粒的冷冻，加速2D晶体结构测定的分子图的准确性和分辨率，通过开发分子置换和相扩展方法； （4）在大型组合研究中，改善了从冷冻物中开始使用相位测定的分子图。 X射线晶体学。有四个主要项目，三个核心和一组相关的项目。主要项目和相关项目的重点是以下生物系统：（1）肌动蛋白细胞骨架； （2）病毒和病毒进入细胞； （3）膜蛋白，尤其是MIP和Mapeg家族的成员； （4）抗生素肽合成酶； （5）剪接组件； （6）T7阶段复制复合物，（“重新组合”）。核心是协作工作的核心组成部分，支持共享的最新电子显微镜设施，软件开发和财团管理。