Hepatitis B & Liver Cancer Prevention in Asian Americans

乙型肝炎

• 批准号: 6916020
• 负责人: JOHN H CHOE
• 金额: $ 20.62万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2007-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6916020
• 关键词: Asian Americans; Chinese American; behavioral /social science research tag; cancer prevention; clinical research; communicable disease control; comprehension; culture; data collection methodology /evaluation; diagnostic tests; education evaluation /planning; health behavior; health disparity; health education; hepatitis B; hepatitis B virus group; human subject; immigrant; liver neoplasms; medically underserved population; method development; questionnaires; racial /ethnic difference

DESCRIPTION (provided by applicant): This Health Protection Research Initiative Mentored Research Scientist Development Award (K01) will provide the candidate, John H. Choe, the multidisciplinary tools to become an independent investigator with special focus on hepatitis B (HBV) and liver cancer control in Asian immigrant populations. Toward this end, Dr. Choe has several related career goals that will be achieved through proposed didactic coursework, clinical training, and mentored research activities. These include: (1) To expand his cancer control research experience by serving as the mentored principal investigator in a vulnerable population; (2) To contribute to the understanding of similarities and differences of disease prevention and cancer control across different Asian populations; (3) To advance cancer control and disease prevention research methodology in Asian Americans by testing the validity of self-reported health behavior; and (4) To submit an R01 grant application addressing hepatitis B and liver cancer prevention in Korean Americans. Largely attributable to high rates of chronic HBV infection and low rates of vaccination, hepatocellular carcinoma (primary liver cancer) affects Asians more than other populations in the US. The proposed research activity would examine rates of HBV and liver cancer testing and vaccination, as well as associations with sociodemographic and other factors, among Korean Americans in Washington State; survey results from Korean Americans will then be compared with those collected previously from the Chinese American community. The research activities proposed for Dr. Choe during this mentored research career development award are: . To develop a culturally-appropriate survey instrument of HBV and liver cancer practices for Korean Americans, incorporating results from a qualitative pilot study and Bastani's Health Behavior Framework. . Using this questionnaire, to identify sociodemographic and other factors associated with recommended HBV testing among 600 ethnic Koreans from the metropolitan area of Tacoma, Washington. . To compare the similarities and differences of factors associated with recommended HBV testing across two Asian American populations: Koreans and Chinese . To conduct a supplemental analysis of the validity of self-reported HBV testing behavior by reviewing a subset of survey participant medical records among Korean and Chinese Americans. . To develop and pre-test a hepatitis B educational intervention for Korean Americans; this will provide feasibility and acceptability information for an intended R01 grant application to address liver cancer in this population.

描述(由申请者提供)：该健康保护研究计划指导研究科学家发展奖(K01)将为候选人John H.Choe提供多学科工具，使其成为一名独立研究员，特别关注亚洲移民人口中的乙肝和肝癌控制。为此，崔博士有几个相关的职业目标，将通过拟议的教学课程、临床培训和有指导的研究活动来实现。这些项目包括：(1)通过在弱势群体中担任指导首席研究员来扩大他的癌症控制研究经验；(2)帮助了解不同亚洲人群在疾病预防和癌症控制方面的异同；(3)通过测试自我报告的健康行为的有效性，推动亚裔美国人的癌症控制和疾病预防研究方法；以及(4)提交针对韩裔美国人的乙肝和肝癌预防的R01拨款申请。 与美国其他人群相比，肝细胞癌(原发肝癌)对亚洲人的影响更大，这在很大程度上是由于慢性乙肝感染率高和疫苗接种率低。拟议的研究活动将检查华盛顿州韩裔美国人中乙肝病毒和肝癌检测和疫苗接种的比率，以及与社会人口和其他因素的关系；然后，将对韩裔美国人的调查结果与以前从华裔美国人社区收集的结果进行比较。在这个指导研究职业发展奖期间，崔博士建议的研究活动包括：为韩裔美国人开发适合文化的乙肝病毒和肝癌实践调查工具，结合定性先导性研究和巴斯塔尼的健康行为框架的结果。 。使用这份问卷，在华盛顿州塔科马地区的600名朝鲜族人中确定与推荐的乙肝病毒检测相关的社会人口学和其他因素。 。比较两个亚裔美国人群体中推荐的乙肝病毒检测相关因素的异同：韩国人和中国人 。通过回顾韩裔和华裔美国人的一组调查参与者的医疗记录，对自我报告的乙肝病毒检测行为的有效性进行补充分析。 。开发和预先测试针对韩裔美国人的乙肝教育干预措施；这将为计划中的R01拨款申请提供可行性和可接受性信息，以解决该人群中的肝癌问题。