PTSD and Depression in Parents of Children with Cancer

癌症儿童父母的创伤后应激障碍和抑郁症

基本信息

  • 批准号:
    6696722
  • 负责人:
  • 金额:
    $ 14.82万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2002
  • 资助国家:
    美国
  • 起止时间:
    2002-02-15 至 2007-01-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): This revised Mentored Career Development application outlines a program of career development and research to study the relationship between hypothalamic-pituitary-adrenal (HPA) axis activity and hippocampal status in acute and chronic stress. Research subjects will consist of parents of children recently diagnosed with cancer. This population is unique because some will develop posttraumatic stress disorder (PTSD) and some will not, but all will undergo chronic stress during the year that they are followed as their child undergoes active cancer treatment Thus, it will be possible to study HPA-axis activity and hippocampal size and morphology in relation to PTSD status and chronic stress over time. I already have a theoretical and applied background in learning, behavior and anxiety. The career development and research plans are designed to enable me to develop proficiency and expertise in the use, analysis and application of neuroendocrinology to measure human stress responses and neuroimaging to address mechanisms of these responses. I will develop and test a theoretical model that examines the interaction between early structural and neuroendocrme abnormalities and subsequent traumatic experiences in a longitudinal design. Mentors include 1) a professor of neurology and director of a neuroimaging center; 2) a psychoneuroendocrinologist with special expertise in the psychobiology of stress and 3) a psychiatrist who is expert in medical trauma anxiety Relevant coursework and laboratory rotations from the curriculum of the Neuroscience Ph.D. program will be completed and mentors will direct in vivo training. Little is known about the time course of human HPA-axis dysregulation associated with exposure to extreme stress. Although previous studies have shown lower cortisol and hippocampal volume reductions in individuals with chronic PTSD, none have assessed HPA status and brain morphology concurrently. In addition, studies have been limited by single assessments often conducted years after the precipitating traumatic event. This proposal aims to investigate immediate and long-term HPA-axis activity and its relation to hippocampal size and morphology in recent-onset trauma. Cancer parents (both genders) with and without PTSD will be assessed within 1 month of the cancer diagnosis, then 12 months post-diagnosis for a) PTSD, depression, and other disorders); b) abnormal neuroendocrine activity (24-hour urinary cortisol) and c) abnormal hippocampal size and morphology (via Magnetic Resonance Imaging). The study will provide much-needed longitudinal data on HPA-axis and hippocampal abnormalities in acute and chronic stress.
描述(由申请人提供):本修订版指导职业发展 申请概述了职业发展和研究计划,以研究 下丘脑-垂体-肾上腺(HPA)轴活动与 急性和慢性应激下的海马状态。研究课题将包括 最近被诊断患有癌症的儿童的父母。这个人口是 独一无二,因为有些人会患上创伤后应激障碍(PTSD),有些人会患上创伤后应激障碍(PTSD) 不会,但所有人都会在他们所在的一年中承受慢性压力 随着他们的孩子接受积极的癌症治疗,因此,这将是 可以研究 HPA 轴活动以及海马大小和形态 与 PTSD 状态和长期压力的关系。我已经有一个 学习、行为和焦虑的理论和应用背景。这 职业发展和研究计划旨在使我能够发展 使用、分析和应用的熟练程度和专业知识 神经内分泌学测量人类应激反应和神经影像学 解决这些响应的机制。我将开发并测试理论 检查早期结构和神经内分泌之间相互作用的模型 纵向设计中的异常和随后的创伤经历。 导师包括 1) 神经病学教授和神经影像学主任 中心; 2) 具有特殊专业知识的心理神经内分泌学家 压力心理生物学和 3) 医学创伤专家的精神科医生 焦虑症课程中的相关课程作业和实验室轮换 神经科学博士项目即将完成,导师将在vivo进行指导 训练。关于人类 HPA 轴失调的时间进程知之甚少 与暴露于极端压力有关。虽然之前的研究已经 研究表明,患有以下疾病的个体皮质醇水平较低,海马体积减少 慢性 PTSD 中,没有人同时评估 HPA 状态和大脑形态。 此外,研究受到经常进行的单一评估的限制 突发性创伤事件发生多年后。该提案旨在 研究近期和长期 HPA 轴活动及其与 近期发生的创伤中海马的大小和形态。癌症父母(均 患有或不患有 PTSD 的性别)将在癌症发生后 1 个月内进行评估 诊断,然后诊断后 12 个月 a) PTSD、抑郁症和其他 疾病); b) 神经内分泌活动异常(24小时尿皮质醇)和 c) 海马大小和形态异常(通过磁共振成像)。 该研究将提供急需的 HPA 轴和 急性和慢性压力下的海马异常。

项目成果

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DOROTHY A GLOVER其他文献

DOROTHY A GLOVER的其他文献

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{{ truncateString('DOROTHY A GLOVER', 18)}}的其他基金

CARING FOR A CHILD WITH SERIOUS ILLNESS PROJECT (CCI PROJECT)
照顾患有严重疾病的儿童项目(CCI 项目)
  • 批准号:
    7724364
  • 财政年份:
    2008
  • 资助金额:
    $ 14.82万
  • 项目类别:
CARING FOR A CHILD WITH SERIOUS ILLNESS PROJECT (CCI PROJECT)
照顾患有严重疾病的儿童项目(CCI 项目)
  • 批准号:
    7627727
  • 财政年份:
    2007
  • 资助金额:
    $ 14.82万
  • 项目类别:
CARING FOR A CHILD WITH SERIOUS ILLNESS PROJECT (CCI PROJECT)
照顾患有严重疾病的儿童项目(CCI 项目)
  • 批准号:
    7369465
  • 财政年份:
    2006
  • 资助金额:
    $ 14.82万
  • 项目类别:
PTSD and Depression in Parents of Children with Cancer
癌症儿童父母的创伤后应激障碍和抑郁症
  • 批准号:
    7006971
  • 财政年份:
    2002
  • 资助金额:
    $ 14.82万
  • 项目类别:
PTSD and Depression in Parents of Children with Cancer
癌症儿童父母的创伤后应激障碍和抑郁症
  • 批准号:
    6438555
  • 财政年份:
    2002
  • 资助金额:
    $ 14.82万
  • 项目类别:
PTSD and Depression in Parents of Children with Cancer
癌症儿童父母的创伤后应激障碍和抑郁症
  • 批准号:
    6846585
  • 财政年份:
    2002
  • 资助金额:
    $ 14.82万
  • 项目类别:
PTSD and Depression in Parents of Children with Cancer
癌症儿童父母的创伤后应激障碍和抑郁症
  • 批准号:
    6622070
  • 财政年份:
    2002
  • 资助金额:
    $ 14.82万
  • 项目类别:
CONTROL AND PREDICTABILITY EFFECTS ON PHOBIC FEAR
对恐惧的控制和可预测性影响
  • 批准号:
    2241964
  • 财政年份:
    1995
  • 资助金额:
    $ 14.82万
  • 项目类别:

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