Cognitive Aging, Brain Morphology, and Arrhythmias in Hispanics/Latinos: Implications for Prevention and Management of Alzheimer's Disease-Related Dementias
西班牙裔/拉丁裔的认知衰老、大脑形态和心律失常:对预防和管理阿尔茨海默病相关痴呆的影响
基本信息
- 批准号:10448081
- 负责人:
- 金额:$ 413.14万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerometerAddressAdultAffectAgeAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAncillary StudyArrhythmiaAtrial FibrillationBlack PopulationsBlack raceBlood PressureBrain InfarctionCardiacCardiovascular DiseasesCerebrovascular TraumaClinicalCognitive agingCommunitiesDataDementiaDiseaseElderlyElectrocardiogramEpidemiologic MethodsEthnic groupFrequenciesFutureGoalsHispanicHispanic Community Health Study/Study of LatinosHispanic PopulationsImaging technologyImpaired cognitionIncidenceIndividualIschemic StrokeKnowledgeLatinoLatino PopulationLife StyleLongevityMagnetic Resonance ImagingMeasuresMinority GroupsMinority Health ResearchMonitorNeurocognitiveObesityParticipantPatternPersonsPhysical activityPopulation HeterogeneityPrevalencePreventionPrevention strategyPublic Health PracticeResearchRiskRisk FactorsStructureSupraventricular ArrhythmiaUnited States National Institutes of HealthVentricular ArrhythmiaVisitadjudicateanalytical methodbasebrain magnetic resonance imagingbrain morphologybrain volumecardiac magnetic resonance imagingcardiovascular disorder riskclinical practicecognitive functioncohortdementia riskexecutive functionhealth disparityheart rhythmhigh riskmiddle agemild cognitive impairmentneuroimagingneurovascular unitnovelprevention clinical trialsymposiumvascular cognitive impairment and dementiavascular injurywearable device
项目摘要
Alzheimer’s Disease (AD) and AD-Related Dementias (ADRD) are projected to affect 115 million people
worldwide by 2050. Vascular contributions to cognitive impairment and dementia (VCID)—a primary type of
ADRD—is a major research focus for the NIH, which has called for the need for studies of prevention across
the lifespan and in diverse populations (ADRD summit 2019). Underrecognized but relevant to VCID, prior
research indicates that arrhythmias are associated with lower cognitive function and greater risk of AD/ADRD.
However, current knowledge of arrhythmias’ neurocognitive impact is lacking in the fastest growing ethnic
group in the USA—Hispanics/Latinos—who are anticipated to contribute disproportionately to the projected
increase in prevalence of mild cognitive impairment (MCI) and ADRD. Thus, robust and comprehensive data
on prevalence and neurocognitive impact of arrhythmias in Hispanics/Latinos are critically needed.
Furthermore, from a prevention standpoint, although prior research shows that modifiable lifestyle and
cardiovascular disease (CVD) risk factors are related to ADRD risk and arrhythmia risk and burden, it is
unknown whether optimizing lifestyle/CVD risk factors can mitigate the arrhythmia-ADRD relationship. To
address the foregoing knowledge gaps, we will apply the ZioXT Patch—a non-invasive ambulatory continuous
ECG monitor—to ~5,000 participants (age ≥45 years) in the Hispanic Community Health Study/Study of
Latinos (HCHS/SOL) in 2022-24 (concurrent with Visit 3) and leverage the rich data in HCHS/SOL and related
ancillary studies: neurocognitive assessment, adjudicated MCI and ADRD, brain MRI, cardiac MRI,
lifestyle/CVD risk factors including 7-day accelerometer-based physical activity, adiposity measures, and blood
pressure. We hypothesize that in Hispanic/Latino adults, higher arrhythmia frequency will be associated with
higher incidence of MCI or ADRD, greater cognitive decline, more brain infarcts and small vessel ischemic
disease, and lower brain volumes. These associations will be independent of CVD and cardiac
structure/function and will be more evident in those with less optimal (vs. more optimal) lifestyle/CVD risk factor
trajectories. We will evaluate these aims: Aim 1: Define the prevalence and frequency of arrhythmias in
Hispanic/Latino adults using ambulatory heart rhythm monitoring, Aim 2: Evaluate the association of
arrhythmias with change in cognitive function and incident MCI or ADRD, Aim 3: Assess the association of
arrhythmias with markers of vascular brain injury based on brain MRI. Importantly, for each Aim, we will
examine the consistency of associations by antecedent 10-year lifestyle/CVD risk factor trajectories. This
project will combine exceptional and complementary scientific expertise, wearable and imaging technology,
rigorous epidemiological and analytical methods, and leverage an existing NIH cohort to refine the VCID
paradigm and overcome critical barriers in AD/ADRD and minority health research, thus achieving a sustained
and powerful impact on public health and clinical practice.
阿尔茨海默病(AD)和AD相关痴呆症(ADRD)预计将影响1.15亿人
到2050年全球血管对认知障碍和痴呆的贡献(VCID)-一种主要类型的
ADRD是NIH的一个主要研究重点,它呼吁需要进行跨学科的预防研究。
寿命和不同人群(ADRD峰会2019)。认识不足但与VCID相关,先前
研究表明,心律失常与认知功能低下和AD/ADRD风险增加有关。
然而,目前的知识心律失常的神经认知影响是缺乏在增长最快的种族,
美国的一个群体--西班牙裔/拉丁裔--预计将对预计的
轻度认知障碍(MCI)和ADRD的患病率增加。因此,可靠和全面的数据
西班牙裔/拉丁裔人群中心律失常的患病率和神经认知影响。
此外,从预防的角度来看,虽然先前的研究表明,改变生活方式和
心血管疾病(CVD)危险因素与ADRD风险和心律失常风险和负担相关,
尚不清楚优化生活方式/CVD风险因素是否可以减轻糖尿病与ADRD的关系。到
为了解决上述知识差距,我们将应用Zio ECONDIX XT贴片-一种非侵入性的非卧床持续性
西班牙裔社区健康研究/研究中的ECG监测仪-约5,000例受试者(年龄≥45岁)
拉丁美洲人(HCHS/SOL)在2022-24年(与访视3同时),并利用HCHS/SOL和相关的丰富数据
辅助研究:神经认知评估、裁定的MCI和ADRD、脑MRI、心脏MRI,
生活方式/CVD风险因素,包括7天基于加速计的体力活动、肥胖测量和血液
压力我们假设,在西班牙裔/拉丁裔成人中,心律失常频率较高与以下因素相关:
MCI或ADRD的发生率更高,认知能力下降更严重,脑梗死和小血管缺血更多
疾病和脑容量降低。这些关联将独立于CVD和心血管疾病
结构/功能,并将在那些不太理想的(与更理想的)生活方式/CVD风险因素更明显
轨迹我们将评估这些目标:目标1:确定心律失常的患病率和频率,
使用动态心律监测的西班牙裔/拉丁裔成人,目标2:评价
心律失常伴认知功能改变与MCI或ADRD事件,目的3:评估
心律失常与基于脑MRI的血管性脑损伤标记物。重要的是,对于每个目标,我们将
通过先前10年的生活方式/心血管疾病风险因素轨迹检查相关性的一致性。这
该项目将结合联合收割机卓越和互补的科学专业知识,可穿戴和成像技术,
严格的流行病学和分析方法,并利用现有的NIH队列来完善VCID
范式,克服AD/ADRD和少数民族健康研究中的关键障碍,从而实现可持续发展。
对公共卫生和临床实践产生了巨大的影响。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Lin Yee Chen其他文献
PO-668-03 GREATER CENTRAL ADIPOSITY IS ASSOCIATED WITH POORER LEFT ATRIAL FUNCTION: THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
PO-668-03 中心性肥胖程度较高与左心房功能较差相关:社区动脉粥样硬化风险(ARIC)研究
- DOI:
10.1016/j.hrthm.2022.03.389 - 发表时间:
2022-05-01 - 期刊:
- 影响因子:5.700
- 作者:
Joseph John Decker;Romil Parikh;Michael Jingyuan Zhang;Alvaro Alonso;Scott D. Solomon;Jeremy Van't Hof;Lin Yee Chen - 通讯作者:
Lin Yee Chen
PO-02-088 FREQUENCY OF EARLY REPOLARIZATION PATTERN AND RISK OF SUDDEN CARDIAC DEATH
PO-02-088 早期复极图形的频率与心脏性猝死的风险
- DOI:
10.1016/j.hrthm.2024.03.820 - 发表时间:
2024-05-01 - 期刊:
- 影响因子:5.700
- 作者:
Daniel Matasic;Rachit M. Vakil;Chukwuka Ibecheozor;Elsayed Z. Soliman;Lin Yee Chen;Michael Hall;Nona Sotoodehnia;Wayne Rosamond;Kunihiro Matsushita;Chiadi Ndumele;Jonathan Chrispin - 通讯作者:
Jonathan Chrispin
Chest Symptoms and Long-Term Risk of Incident Cardiovascular Disease
- DOI:
10.1016/j.amjmed.2024.07.009 - 发表时间:
2024-12-01 - 期刊:
- 影响因子:
- 作者:
Kentaro Ejiri;Yejin Mok;Ning Ding;Patricia P. Chang;Wayne D. Rosamond;Amil M. Shah;Pamela L. Lutsey;Lin Yee Chen;Michael J. Blaha;Lena Mathews;Kunihiro Matsushita - 通讯作者:
Kunihiro Matsushita
ASSOCIATION OF SILENT MYOCARDIAL INFARCTION WITH COGNITIVE DECLINE OVER 25 YEARS: RESULTS FROM THE ARIC-NCS (ATHEROSCLEROSIS RISK IN COMMUNITIES NEUROCOGNITIVE STUDY)
25 年以上沉默型心肌梗死与认知功能下降的关联:来自 ARIC-NCS(社区动脉粥样硬化风险神经认知研究)的结果
- DOI:
10.1016/s0735-1097(25)02367-8 - 发表时间:
2025-04-01 - 期刊:
- 影响因子:22.300
- 作者:
Mohamed A. Mostafa;Christopher Schaich;Faye Norby;Richard Kazibwe;Lingyi Lu;Lin Yee Chen;Timothy Hughes;Elsayed Z. Soliman - 通讯作者:
Elsayed Z. Soliman
ECG-AI: AN EXTERNALLY VALIDATED DEEP LEARNING MODEL TO PREDICT HEART FAILURE RISK
- DOI:
10.1016/s0735-1097(22)01319-5 - 发表时间:
2022-03-08 - 期刊:
- 影响因子:
- 作者:
Oguz Akbilgic;Liam Butler;Ibrahim Karabayir;Dalane W. Kitzman;Gari Clifford;Lin Yee Chen;Alvaro Alonso;Patricia P. Chang;Elsayed Z. Soliman - 通讯作者:
Elsayed Z. Soliman
Lin Yee Chen的其他文献
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{{ truncateString('Lin Yee Chen', 18)}}的其他基金
Cognitive Impairment and Dementia, Vascular Brain Injury, and Atrial Myopathy: Implications for Prevention of Alzheimer's Disease-Related Dementias
认知障碍和痴呆、血管性脑损伤和心房肌病:对预防阿尔茨海默病相关痴呆的影响
- 批准号:
10814076 - 财政年份:2023
- 资助金额:
$ 413.14万 - 项目类别:
Glucose patterns and cardiac arrhythmias in older adults with diabetes
老年糖尿病患者的血糖模式和心律失常
- 批准号:
10360749 - 财政年份:2022
- 资助金额:
$ 413.14万 - 项目类别:
Novel application of Digital signals of movement, sleep and heart rhythms for detection of Alzheimer's Disease and Related Dementias
运动、睡眠和心律数字信号在阿尔茨海默病和相关痴呆症检测中的新应用
- 批准号:
10710169 - 财政年份:2022
- 资助金额:
$ 413.14万 - 项目类别:
Glucose patterns and cardiac arrhythmias in older adults with diabetes
老年糖尿病患者的血糖模式和心律失常
- 批准号:
10597965 - 财政年份:2022
- 资助金额:
$ 413.14万 - 项目类别:
Novel application of Digital signals of movement, sleep and heart rhythms for detection of Alzheimer's Disease and Related Dementias
运动、睡眠和心律数字信号在阿尔茨海默病和相关痴呆症检测中的新应用
- 批准号:
10525869 - 财政年份:2022
- 资助金额:
$ 413.14万 - 项目类别:
Mentoring and Research to ClassifyAtrial Cardiomyopathy
心房心肌病分类的指导和研究
- 批准号:
10439909 - 财政年份:2021
- 资助金额:
$ 413.14万 - 项目类别:
Mentoring and Research to ClassifyAtrial Cardiomyopathy
心房心肌病分类的指导和研究
- 批准号:
10640951 - 财政年份:2021
- 资助金额:
$ 413.14万 - 项目类别:
Mentoring and Research to Classify Atrial Cardiomyopathy
心房心肌病分类的指导和研究
- 批准号:
10307378 - 财政年份:2021
- 资助金额:
$ 413.14万 - 项目类别:
Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive Decline
左心房异常和心房颤动相关的脑梗塞和认知能力下降
- 批准号:
9495380 - 财政年份:2018
- 资助金额:
$ 413.14万 - 项目类别:
Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive Decline
左心房异常和心房颤动相关的脑梗塞和认知能力下降
- 批准号:
9900061 - 财政年份:2018
- 资助金额:
$ 413.14万 - 项目类别:
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