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Receptor interactions of Coronaviruses as an antiviral target and determinant of cell tropism and pathogenicity

冠状病毒的受体相互作用作为抗病毒靶点以及细胞趋向性和致病性的决定因素

基本信息

批准号：
2424679
负责人：
金额：
--
依托单位：
University of Oxford
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2019
资助国家：
英国
起止时间：
2019 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2424679
关键词：
Receptor interactions Coronaviruses antiviral target

项目摘要

Poultry infected with viral diseases- including avian influenza viruses, Infectious Bronchitis virus and/or Newcastle disease viruses- suffer severe morbidity and mortality which gravely impacts the global poultry production and the industry as a whole. Zoonotic transmission of avian influenza has also resulted in extensive human infection. Effective control of these viruses in poultry is complex, with current interventions involving culling of infected and at-risk poultry, restrictions to poultry movement and routine sampling and surveillance. The impact of disease is reduced through vaccination; however, available vaccines do not guarantee complete protection or sterile immunity.This PhD project will evaluate the antiviral potential and molecular properties of egg derived proteins for use in a novel prophylactic treatment of farmed poultry against poultry viral diseases. Preliminary data shows the identified candidates are able to inhibit the haemagglutination ability of different viruses. The antiviral activities of the identified proteins will be evaluated using virological approaches including the use of cell culture, embryonated chicken eggs and in vivo chicken infection models. The follow-on studies will analyse molecular properties of these naturally derived molecules and exploit molecular biology, biotechnology technologies to produce more stable antiviral therapeutics in vitro in cell culture systems.

感染病毒性疾病（包括禽流感病毒、传染性支气管炎病毒和/或纽卡斯尔病病毒）的家禽遭受严重的发病率和死亡率，这严重影响了全球家禽生产和整个行业。人畜共患禽流感的传播也导致了广泛的人类感染。有效控制家禽中的这些病毒是复杂的，目前的干预措施包括扑杀受感染和有风险的家禽，限制家禽流动以及例行采样和监测。通过疫苗接种可以减少疾病的影响;然而，现有的疫苗并不能保证完全保护或无菌免疫。该博士项目将评估蛋源蛋白的抗病毒潜力和分子特性，用于养殖家禽对抗家禽病毒性疾病的新型预防性治疗。初步数据显示，所鉴定的候选物能够抑制不同病毒的血凝能力。将使用病毒学方法（包括使用细胞培养物、含胚鸡蛋和体内鸡感染模型）评价鉴定的蛋白质的抗病毒活性。后续研究将分析这些天然衍生分子的分子特性，并利用分子生物学和生物技术在体外细胞培养系统中生产更稳定的抗病毒治疗药物。