Soluble Peracid Powders for Medical Device Disinfection

描述（由申请人提供）：内窥镜的高度专业化用途及其高昂的资本支出使大多数机构无法拥有大量内窥镜。因此，有必要对内窥镜进行快速清洁和消毒，以便它们可以重复使用。内窥镜的这种快速周转使得快速清洁和消毒方法受到高度重视。最常用的内窥镜消毒方法是将其浸入市售的液体化学杀菌剂中，该杀菌剂含有稀释浓度的戊二醛或过氧乙酸。然而，戊二醛是有毒的，并且使用戊二醛所需的消毒周期太长。过氧乙酸基杀菌剂消毒快得多，但由于它们在稀释溶液中的稳定性差，这些杀菌剂作为危险的浓缩液体储存。本修订的I期提案描述了一种新型过氧化合物家族及其消毒内窥镜能力的评价。这些化合物可以合成和分离为固体，浓缩粉末，具有延长的保质期。这些粉末可溶于水，因此在需要时可以安全且容易地制备大量的液体消毒剂。这些过氧化合物提供了具有浓缩粉末的安全和方便性质的过乙酸的期望性质。 关键词：内窥镜，灭菌，过酸，孢子，消毒，冷灭菌剂，过氧化合物，液体化学杀菌剂。 商业应用：该技术的商业应用相当可观。固体过氧化合物将优于目前工业中使用的危险浓缩溶液。从廉价的起始材料一步合成这些化合物是简单的。拟议的技术将首先引入内窥镜再处理行业，随后将引入其他高水平消毒市场。

DESCRIPTION (provided by applicant): The highly specialized uses for endoscopes and their high capital expense preclude most facilities from owning very many of them. Therefore, it is necessary to rapidly clean and disinfect endoscopes so they can be reused. This rapid turn-around of endoscopes places a high premium on expeditious cleaning and disinfection methods. The most popular method of disinfecting endoscopes is to immerse them in a commercially available liquid chemical germicide that contains dilute concentrations of either glutaraldehyde or peracetic acid. However, glutaraldehyde is toxic and disinfection cycles that use glutaraldehyde require are too long. Peracetic acid-based germicides disinfect much faster but because of their poor stability in dilute solutions, these germicides are stored as hazardous concentrated liquids. This revised Phase I proposal describes the evaluation of a novel family of peroxygen compounds and their capability to disinfect endoscopes. These compounds can be synthesized and isolated as solid, concentrated powders with an extended shelf-life. The powders are soluble in water so that large quantities of liquid disinfectant can be safely and easily prepared, when desired. These peroxygen compounds provide the desirable properties of peracetic acid with the safe and convenient properties of a concentrated powder. Key Words: Endoscope, sterilization, peracids, spores, disinfection, cold sterilants, peroxygen compounds, liquid chemical germicides. Commercial Applications: The commercial applications for this technology are considerable. The solid peroxygen compounds will be preferred over the hazardous concentrated solutions currently used in the industry. The one-step synthesis of these compounds from inexpensive starting materials is straightforward. The proposed technology will be first introduced into the endoscope reprocessing industry and will be followed by the introduction into other high-level disinfection markets.