Soluble Peracid Powders for Medical Device Disinfection

用于医疗器械消毒的可溶性过酸粉末

• 批准号: 6645725
• 负责人: G DUNCAN HITCHENS
• 金额: $ 10.91万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6645725
• 关键词: antiseptic sterilization; biomedical equipment safety; biotechnology; chemical synthesis; communicable disease control; disinfectants; endoscopy; oxygen compounds; peroxides

DESCRIPTION (provided by applicant): The highly specialized uses for endoscopes and their high capital expense preclude most facilities from owning very many of them. Therefore, it is necessary to rapidly clean and disinfect endoscopes so they can be reused. This rapid turn-around of endoscopes places a high premium on expeditious cleaning and disinfection methods. The most popular method of disinfecting endoscopes is to immerse them in a commercially available liquid chemical germicide that contains dilute concentrations of either glutaraldehyde or peracetic acid. However, glutaraldehyde is toxic and disinfection cycles that use glutaraldehyde require are too long. Peracetic acid-based germicides disinfect much faster but because of their poor stability in dilute solutions, these germicides are stored as hazardous concentrated liquids. This revised Phase I proposal describes the evaluation of a novel family of peroxygen compounds and their capability to disinfect endoscopes. These compounds can be synthesized and isolated as solid, concentrated powders with an extended shelf-life. The powders are soluble in water so that large quantities of liquid disinfectant can be safely and easily prepared, when desired. These peroxygen compounds provide the desirable properties of peracetic acid with the safe and convenient properties of a concentrated powder. Key Words: Endoscope, sterilization, peracids, spores, disinfection, cold sterilants, peroxygen compounds, liquid chemical germicides. Commercial Applications: The commercial applications for this technology are considerable. The solid peroxygen compounds will be preferred over the hazardous concentrated solutions currently used in the industry. The one-step synthesis of these compounds from inexpensive starting materials is straightforward. The proposed technology will be first introduced into the endoscope reprocessing industry and will be followed by the introduction into other high-level disinfection markets.

描述（由申请人提供）：内窥镜的高度专业化用途及其高昂的资本支出使大多数设施无法拥有大量内窥镜。因此，有必要快速清洁和消毒内窥镜，使其可以重复使用。这种快速周转的内窥镜对快速清洁和消毒方法提出了很高的要求。最流行的内窥镜消毒方法是将它们浸入市售的含有稀释浓度戊二醛或过氧乙酸的液体化学杀菌剂中。然而，戊二醛是有毒的，使用戊二醛需要的消毒周期太长。过氧乙酸基杀菌剂消毒速度快得多，但由于它们在稀释溶液中的稳定性差，这些杀菌剂被作为危险的浓缩液体储存。这个修订的I期提案描述了一个新的过氧化合物家族及其消毒内窥镜的能力的评估。这些化合物可以合成和分离为固体浓缩粉末，具有延长的保质期。粉末可溶于水，因此，当需要时，可以安全方便地制备大量液体消毒剂。这些过氧化合物提供了过氧乙酸所需的性能和浓缩粉末的安全和方便的性能。