Towards the development of a point-of-care detection system for acute respiratory infections

开发急性呼吸道感染即时检测系统

• 批准号: 2426460
• 金额: --
• 依托单位: CARDIFF UNIVERSITY
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2426460
• 关键词: Towards; development; point; care; detection

Pneumonia remains the leading cause of death in children under 5 worldwide, killing an estimated 1.4 million children each year. In order to improve clinical outcomes, appropriate treatment(s) need to be started as soon as possible. It is therefore essential that a definitive diagnosis can be made in a timely manner. Using microwave-assisted sample-preparation techniques, this project will focus on isolating both pathogen and host biomarkers associated with childhood pneumonia. Molecular probes will be designed against these target markers for integration with a number of state-of-the-art biosensing systems under development within the IDTH. The project will involve: Selection of pathogen and host biomarkers associated with acute respiratory infectionsDesign of molecular probes that recognise selected markersImmobilisation of probes to metal surfaces for integration within a biosensing system

肺炎仍然是全世界5岁以下儿童死亡的主要原因，估计每年造成140万儿童死亡。为了改善临床结局，需要尽快开始适当的治疗。因此，及时做出明确诊断至关重要。利用微波辅助样品制备技术，该项目将重点分离与儿童肺炎相关的病原体和宿主生物标志物。将针对这些目标标记物设计分子探针，用于与IDTH内正在开发的许多最先进的生物传感系统集成。该项目将涉及：选择与急性呼吸道感染相关的病原体和宿主生物标志物设计识别选定标志物的分子探针将探针固定到金属表面以整合到生物传感系统中