Core--Anatomic and Functional Imaging

解剖和功能成像核心的主要目标是为P01项目提供广泛的以研究为基础的成像技术；支持由训练有素的专业成像医生、科学家和技术员组成的复杂核心；以及开展旨在通过临床和临床前研究改进多发性骨髓病(MM)诊断、预后和治疗的研究所需的数据库维护和数据关联支持。这些目标将通过以下具体目标的实现来实现：具体目标1。为骨髓瘤患者和动物模型提供解剖和功能成像。核心将汇集最先进的解剖和功能成像资源，以提供必要的特定成像能力，使每个P01项目能够实现其各自的目标。这一令人印象深刻的技术支持将由一个由2名放射科医生组成的专门团队提供，他们拥有广泛的机构支持，并得到在所用方式方面世界知名的顾问和合作者的协助。具体目的2.进行引导活检，为患者和动物模型、骨骼系统和软组织中的疾病分布提供快速和准确的视觉评估。这项服务将使研究人员能够识别代谢最活跃的区域(前哨病变)。具体目标3.维护和关联解剖和功能成像研究的数据库。核心B将继续维护数据库(即核磁共振扫描、骨骼测量、氟脱氧葡萄糖(FDG)正电子发射计算机断层扫描、CT检查结果等)。在本供资周期内已经在使用，并在需要时建立新的数据库。数据库包含每个发现的量化结果，即 专业成像专家认为，这与所涉及的医疗方式有关。这些数据库定期转换为Excel电子表格格式，并通过电子邮件发送给癌症研究和生物统计提供商进行数据分析和关联，这一过程已经导致 对多发性骨髓瘤的生物学行为有许多新的见解。因此，通过提供解剖和功能成像，以及数据库管理和与临床数据的关联，Core B将使P01项目能够进行旨在通过临床和临床前研究改善多发性骨髓瘤诊断、预后和治疗的研究。

The primary objectives of this core, the Anatomic and Functional Imaging Core, are to provide P01 projects with an extensive array of research-based imaging technologies; the support of a sophisticated core of highly trained professional imaging physicians, scientists, and technologists; and the database maintenance and data correlation support required to pursue research aimed at improving multiple myelosis (MM) diagnosis, prognosis, and treatment through clinical and preclinical research. These objectives will be met through the accomplishment of the following specific aims: Specific Aim 1. Offer anatomic and functional imaging for myeloma patients and animal models. The core will bring together state-of-the-art anatomic and functional imaging resources to provide the specific imaging capabilities necessary to enable each P01 project to accomplish its individual aims. This impressive technological support will be delivered by a dedicated team of 2 radiologists with extensive institutional support and the assistance of consultants and collaborators who are world-renown in the modalities used. Specific Aim 2. Perform guided biopsies providing rapid and accurate visual assessment of disease distribution in patients and animal models, in the skeletal system, and in soft tissues. This service will allow investigators to identify the most metabolically active regions (sentinel lesions). Specific Aim 3. Maintain and correlate databases from anatomic and functional imaging studies. Core B will continue to maintain databases (i.e., MRI scans, skeletal surveys, fluorodeoxyglucose (FDG) PET scans, CT findings, etc.) already in use during the current funding cycle, and establish new databases as needed. Databases contain quantitative results of each finding that the professional imaging specialists feel is relevant for the modality involved. These databases are periodically converted to an Excel spreadsheet format and e-mailed to Cancer Research and Biostatistics providers for data analysis and correlation, a process that has already resulted in many new insights into the biological behavior of multiple myeloma. Thus, by providing anatomic and functional imaging, as well as database management and correlation with clinical data, Core B will enable P01 projects to pursue research aimed at improving MM diagnosis, prognosis, and treatment through clinical and preclinical research.